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Saturday, December 17, 2011
Friday, December 16, 2011
Team designs a bandage that spurs, guides blood vessel growth
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Public release date: 15-Dec-2011[ | E-mail |
Share ] Contact: Diana Yates, Life Sciences Editor
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
CHAMPAIGN, Ill. -- Researchers have developed a bandage that stimulates and directs blood vessel growth on the surface of a wound. The bandage, called a "microvascular stamp," contains living cells that deliver growth factors to damaged tissues in a defined pattern. After a week, the pattern of the stamp "is written in blood vessels," the researchers report.
A paper describing the new approach will appear as the January 2012 cover article of the journal Advanced Materials.
"Any kind of tissue you want to rebuild, including bone, muscle or skin, is highly vascularized," said University of Illinois chemical and biomolecular engineering professor Hyunjoon Kong, a co-principal investigator on the study with electrical and computer engineering professor Rashid Bashir. "But one of the big challenges in recreating vascular networks is how we can control the growth and spacing of new blood vessels."
"The ability to pattern functional blood vessels at this scale in living tissue has not been demonstrated before," Bashir said. "We can now write features in blood vessels."
Other laboratories have embedded growth factors in materials applied to wounds in an effort to direct blood vessel growth. The new approach is the first to incorporate live cells in a stamp. These cells release growth factors in a more sustained, targeted manner than other methods, Kong said.
The stamp is nearly 1 centimeter across and is built of layers of a hydrogel made of polyethylene glycol (an FDA-approved polymer used in laxatives and pharmaceuticals) and methacrylic alginate (an edible, Jell-O-like material). The stamp is porous, allowing small molecules to leak through, and contains channels of various sizes to direct the flow of larger molecules, such as growth factors.
The researchers tested the stamp on the surface of a chicken embryo. After a week the stamp was removed, revealing a network of new blood vessels that mirrored the pattern of the channels in the stamp.
"This is a first demonstration that the blood vessels are controlled by the biomaterials," Kong said.
The researchers see many potential applications for the new stamp, from directing the growth of blood vessels around a blocked artery, to increasing the vascularization of tissues with poor blood flow, to "normalizing" blood vessels that feed a tumor to improve the delivery of anti-cancer drugs. Enhancing the growth of new blood vessels in a coordinated pattern after surgery may also reduce recovery time and lessen the amount of scar tissue, the researchers said.
In another study published in 2011, the team developed a biodegradable material that supports living cells. Future research will test whether the new material also can be used a stamp.
###
Researchers on the study team also included K. Jimmy Hsia, a professor of mechanical science and engineering and of bioengineering at Illinois; postdoctoral researchers Jae Hyun Jeong and Pinar Zorlutuna; and graduate students Vincent Chan, Chaenyung Cha and Casey Dyck.
This study was supported in part by the National Science Foundation Emergent Behaviors of Integrated Cellular Systems Center at Illinois, Georgia Institute of Technology and Massachusetts Institute of Technology; the U.S. Army Telemedicine & Advanced Technology Research Center; an NSF Career grant; the American Heart Association; and the Amore Pacific Corp.
Bashir, the Abel Bliss Professor of Engineering, also is a professor of bioengineering. He and Kong are affiliates of the Micro and Nanotechnology Lab and the Institute for Genomic Biology at Illinois.
Editor's notes: To reach Hyunjoon Kong, call 217-333-1178; email hjkong06@illinois.edu. To reach Rashid Bashir, email rbashir@illinois.edu.
The paper, "Living Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry," is available online and from the U. of I. News Bureau.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 15-Dec-2011[ | E-mail |
Share ] Contact: Diana Yates, Life Sciences Editor
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
CHAMPAIGN, Ill. -- Researchers have developed a bandage that stimulates and directs blood vessel growth on the surface of a wound. The bandage, called a "microvascular stamp," contains living cells that deliver growth factors to damaged tissues in a defined pattern. After a week, the pattern of the stamp "is written in blood vessels," the researchers report.
A paper describing the new approach will appear as the January 2012 cover article of the journal Advanced Materials.
"Any kind of tissue you want to rebuild, including bone, muscle or skin, is highly vascularized," said University of Illinois chemical and biomolecular engineering professor Hyunjoon Kong, a co-principal investigator on the study with electrical and computer engineering professor Rashid Bashir. "But one of the big challenges in recreating vascular networks is how we can control the growth and spacing of new blood vessels."
"The ability to pattern functional blood vessels at this scale in living tissue has not been demonstrated before," Bashir said. "We can now write features in blood vessels."
Other laboratories have embedded growth factors in materials applied to wounds in an effort to direct blood vessel growth. The new approach is the first to incorporate live cells in a stamp. These cells release growth factors in a more sustained, targeted manner than other methods, Kong said.
The stamp is nearly 1 centimeter across and is built of layers of a hydrogel made of polyethylene glycol (an FDA-approved polymer used in laxatives and pharmaceuticals) and methacrylic alginate (an edible, Jell-O-like material). The stamp is porous, allowing small molecules to leak through, and contains channels of various sizes to direct the flow of larger molecules, such as growth factors.
The researchers tested the stamp on the surface of a chicken embryo. After a week the stamp was removed, revealing a network of new blood vessels that mirrored the pattern of the channels in the stamp.
"This is a first demonstration that the blood vessels are controlled by the biomaterials," Kong said.
The researchers see many potential applications for the new stamp, from directing the growth of blood vessels around a blocked artery, to increasing the vascularization of tissues with poor blood flow, to "normalizing" blood vessels that feed a tumor to improve the delivery of anti-cancer drugs. Enhancing the growth of new blood vessels in a coordinated pattern after surgery may also reduce recovery time and lessen the amount of scar tissue, the researchers said.
In another study published in 2011, the team developed a biodegradable material that supports living cells. Future research will test whether the new material also can be used a stamp.
###
Researchers on the study team also included K. Jimmy Hsia, a professor of mechanical science and engineering and of bioengineering at Illinois; postdoctoral researchers Jae Hyun Jeong and Pinar Zorlutuna; and graduate students Vincent Chan, Chaenyung Cha and Casey Dyck.
This study was supported in part by the National Science Foundation Emergent Behaviors of Integrated Cellular Systems Center at Illinois, Georgia Institute of Technology and Massachusetts Institute of Technology; the U.S. Army Telemedicine & Advanced Technology Research Center; an NSF Career grant; the American Heart Association; and the Amore Pacific Corp.
Bashir, the Abel Bliss Professor of Engineering, also is a professor of bioengineering. He and Kong are affiliates of the Micro and Nanotechnology Lab and the Institute for Genomic Biology at Illinois.
Editor's notes: To reach Hyunjoon Kong, call 217-333-1178; email hjkong06@illinois.edu. To reach Rashid Bashir, email rbashir@illinois.edu.
The paper, "Living Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry," is available online and from the U. of I. News Bureau.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2011-12/uoia-tda121511.php
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Dell unveils new Alienware Aurora gaming PC | Ubergizmo
The Aurora will feature Intel?s second-generation 3000 series Core i7 six-core CPU, the X79 Express chipset, Quad Channel DDR3 memory and will be overclocked for what they?re calling, ?extreme gaming performance?. It will feature a liquid cooling system and active venting as well as you can see from the air vents on top of the chassis.
Customers will be able to select from a variety of GDDR5 GPUs, and will be able to support both multi-display and 3D configurations. The system is highly configurable and users will be able to configure it to their hearts? content on Dell?s website. So how much will all of this cost you? The base price alone will set you back $2,199 which we imagine will only get higher the more you configure it.
If you?d like to see how much the gaming rig of your dreams could cost you, or if you?d like more information on the Alienware Aurora, head on down to Dell?s website where you will be able to configure the gaming rig to your specifications.
Source: http://www.ubergizmo.com/2011/12/dell-unveils-new-alienware-aurora-gaming-pc/
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Wednesday, December 7, 2011
Cores reveal when Dead Sea 'died'
5 December 2011
Last updated at 20:38 ET
Sediments drilled from beneath the Dead Sea reveal that this most remarkable of water bodies all but disappeared 120,000 years ago.
It is a discovery of high concern say scientists because it demonstrates just how dry the Middle East can become during Earth's warm phases.
In such ancient times, few if any humans were living around the Dead Sea.
Today, its feed waters are intercepted by large populations and the lake level is declining rapidly.
"The reason the Dead Sea is going down is because virtually all of the fresh water flowing into it is being taken by the countries around it," said Steve Goldstein, a geochemist at Columbia University's Lamont-Doherty Earth Observatory, US.
"But we now know that in a previous warm period, the water that people are using today and are relying upon stopped flowing all by itself. That has important implications for people today because global climate models are predicting that this region in particular is going to become more arid in the future," he told BBC News.
Prof Goldstein has been presenting the results of the drilling work here at the 2011 American Geophysical Union (AGU) Fall Meeting, the largest annual gathering of Earth scientists.
The Dead Sea is an extraordinary place. The surface of the inland waterway sits at the lowest land point on the planet, more than 400m below sea level.
Its hyper-salty waters descend in places a further 300m. And below the lake bed is layer upon layer of sediments that record the Dead Sea's history and the climate conditions that have prevailed in the region over hundreds of thousands of years.
A consortium of investigators from Israel, the US, Germany, Japan, Switzerland and Norway drilled two cores into the Dead Sea's bed in late 2010. One of them was centred close to the very deepest part of the lake.
At 235m down, the consortium hit a layer of small, rounded pebbles - what the team believes are the deposits of an ancient beach. Given the location of the core, this would suggest the Dead Sea had a complete, or near, dry-down at some point in the past.
Formal dating of the core sediments has not yet been completed, but their pattern leads the team to conclude that the dry-down occurred in the Eemian.
This was a stage in Earth history when global temperatures were as warm, if not slightly warmer, than they are today.
The modern day Middle East is preventing water getting into the Dead Sea. The surrounding countries are using it for agriculture. Fertiliser and salt manufacturing are also having an impact. Since 1997, the lake's surface has fallen more than 10m.
"Lake dry-down happened 120,000 years ago without any human intervention," said Prof Emi Ito, from the University of Minnesota, Minneapolis. "We're helping the lake level go down much sooner; and there are political implications of this lake drying down because water is what causes a lot of wars and I'll just leave it at that."
Prof Zvi Ben-Avraham, of the Minerva Dead Sea Research Centre, Tel Aviv University, added: "The drilling actually... it gives us perspective. Look what went on in 200,000 years; look how the area can be dry and look at the way it can be recovered. We have to get ready for the future."
Past research has shown very clearly how the size of the Dead Sea has fluctuated with the coming and going of ice ages.
During the interglacials (warm periods), the lake shrank; and during glacials (cold phases), the lake grew. And it was in the midst of the last ice age some 25,000 years ago that the Dead Sea reached its maximum extent, with the then water surface standing an astonishing 260m above where it is today.
This giant palaeo-lake, referred to by scientists as Lake Lisan, would have inundated the whole Dead Sea valley, even encompassing the Sea of Galilee to the north.
The consortium has traced these changes in the laminated sediments that line the surrounding cliffs and hills.
It is possible to see exquisite, alternating bands of light (aragonite) and dark (marl) material in the exposed rock.
The light layers are calcium carbonate precipitated out of the water in warm summer months. The dark bands are winter silts washed into the Dead Sea by storms.
But it is also possible to find layers of calcium sulphate (gypsum) and even salt, which relate to extended periods of dry weather when feed waters to the Dead Sea have not kept pace with evaporation.
"All these deposits from the last ice age are sitting at the edge of the lake, and we've been studying them for 20 years," said Prof Goldstein.
"They're beautifully exposed, but? as soon as we have a warm age, like we have today and like we had before the last ice age, the lake is lower and we have no exposures we can use. The only way we can get to those time periods is to have a deep drill core," he told BBC News.
Source: http://www.bbc.co.uk/go/rss/int/news/-/news/science-environment-15938294
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Tuesday, December 6, 2011
Angelina Jolie On Marriage: Six Children Are Enough Of A Commitment (VIDEO)
Just three years after Pitt and Jolie met on the set of Mr. And Mrs. Smith, OK! Magazine claimed that the couple was set for a "fairytale Christmas wedding in South Africa." One source told the magazine: "They are treating their marriage like a spiritual affirmation and don't need big Hollywood glitz like Tom Cruise had in Italy."
Source: http://www.huffingtonpost.com/2011/12/05/angelina-jolie-marriage_n_1129641.html
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Monday, December 5, 2011
McCain: Billions in US aid to Pakistan in jeopardy (AP)
WASHINGTON ? Sen. John McCain says the billions of U.S. aid to Pakistan must come with strings attached.
The top Republican on the Senate Armed Services Committee, which helps to oversee that money, says Pakistan should show it's helping to "prevent the needless deaths of young Americans."
McCain's comment on CNN's "State of the Union" shows the acute frustration in Congress because of alleged ties between Pakistan's intelligence outfit and anti-U.S. insurgents.
U.S.-Pakistan relations have become even more strained after NATO airstrikes killed 24 Pakistani troops along the Afghanistan border. Pakistan retaliated by shutting down U.S. supply lines.
The Arizona lawmaker says the U.S. should "explore all alternatives," although he did not provide specifics.
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