Tuesday, December 4, 2012

Follow Jeff Bezos' Two Pizza Rule to Avoid the Dangers of "Groupthink"

Follow Jeff Bezos' Two Pizza Rule to Avoid the Dangers of "Groupthink"You may have heard the joke that asserts a camel is just a horse designed by a committee. The truth behind the humor is that groups suffer from something called "groupthink," which means they tend to lose the benefits of independent thought and just agree with each other. Everyone ends up patting themselves on the back rather than creating something great. Amazon founder and CEO Jeff Bezos solves that problem with a two-pizza rule.

According to productivity and ideas blog the 99u, Bezos uses pizza as a metric for choosing the size of his teams. Basically, if a team can't be fed be two pizzas alone that team is too large. The brain can't handle a lot of people, so it's not a surprise that smaller teams tend to work better. If you find independent ideas are suffering in your organization, it might be time to suggest instituting the two pizza rule. At the very least, you might get a free meal out of it.

The Jeff Bezos School of Long-Term Thinking | The 99u

Photo by Fanfo (Shutterstock).

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/BKnXYRuMD4M/follow-jeff-bezos-two-pizza-rule-to-avoid-the-dangers-of-groupthink

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Video: Creating Jobs For Texas

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Source: http://video.msnbc.msn.com/cnbc/50068866/

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Get Your Finances in Order: a Few Tips | Personal Finance Blog ...

As we linger in the midst of post-recession and mild austerity, making and saving money may seem a tough task for many. However, there are a few canny little tricks that can be used to our advantages to make this task somewhat easier for many. Here?s some advice on getting your finances in order.

Say No to Payday Loans!

Due to the current economic climate and of course, the individual and personal throes of life, many Brits are struggling to make ends meet. Jobs are scarce, even many of those lucky enough to be working feel as if they?re being underpaid. Furthermore, rising living costs make most wages hard to survive off in the United Kingdom. In fact, recent reports have highlighted that more and more children are being forced to go to school hungry, due to a lack of resources at home.

To make things even worse, bank lending has somewhat subsisted since the recession and so, many Brits are unable to borrow off banks.

In such a climate, payday loans may seem to be an enticing option. However, a combination of immoral practices and extortionately high interest rates render payday loans as the worst option someone in financial difficulty could turn to. Payday loans may put food on the table and alleviate some of your financial distress for a moment, but this will only be a fleeting moment, which will end with you having even more money problems than prior to taking out the loan.

Say no to payday loans.

Tax Refunds

It may come as somewhat of a surprise, but a significant amount of business people miss out on thousands of pounds owed to them by the HMRC each year. In cases where the tax liability is less than the amount paid, money is likely to be owed to the payer in the form of tax refunds.

This can happen through a wide variety of circumstances and it may be best for you to hire expert assistance to discern whether or not you?re owed anything. However, rather than going for an expensive accountant, opt for one of the cheaper specialist firms that can be found online, such as RIFT at www.RIFTCapitalAllowances.com.

Work Harder, Earn More Money

The harder you work the more money you?ll earn. It really is as simple as that. Of course, the current situation in Britain at the moment is one of mass unemployment and a lack of job opportunities. However, working harder also applies to the unemployed, who have a responsibility to work harder in finding work.

After all, the more time you spend looking for a job, the more chances there?ll be of finding one.

Source: http://www.personal-finance-blog.com/2012/12/02/get-your-finances-in-order-a-few-tips/

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Mars Rover Finds Complex Chemicals But No Organic Compounds

techtech writes in with the results from the first soil samples tested by the Curiosity rover. "Although NASA's Curiosity rover hasn't yet confirmed the detection of organic compounds on Mars, it's already seeing that the Red Planet's soil contains complex chemicals ? including signs of an intriguing compound called perchlorate. The first soil sample analysis from Curiosity's Sample Analysis at Mars lab, or SAM, was the leadoff topic today at the American Geophysical Union's fall meeting in San Francisco. The findings were eagerly awaited because of rumors that the Curiosity team was on the verge of announcing major findings ? and although NASA tamped down expectations, the scientists said they were overjoyed with the first round of analysis."

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/gIuzuWSw5OU/story01.htm

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Monday, December 3, 2012

The five family holiday shows you don't want to miss: Lively theater ...

What is your favorite childhood memory of the holidays? Playing with cousins while waiting for Santa? Singing carols with friends at school? Sipping hot chocolate with parents while reading holiday books?

In our hearts we carry a range of remembrances from the simplest pleasures to the most lavish spectacles. This holiday season, Houston?s performance halls are offering shows that can delight the whole family and leave indelible impressions of the holiday spirit.

Here are five favorite choices:

A Little House Christmas

When: Through Dec. 22; Saturdays at 1 p.m. and 4 p.m.

Where: Main Street Theater, Chelsea Market, 4617 Montrose Blvd., 713-524-6706, www.mainstreettheater.com

Storyline:? This play is based on the cherished Little House books by Laura Ingalls Wilder. Bad weather hampers the Ingalls family?s Christmas Day celebration. Sisters Laura and Mary are disappointed that they are stranded at home and Santa may not make it after all. In this holiday classic, the girls learn the true meaning of the Christmas spirit.

"The Little House books are timeless, and A Little House Christmas is such a warm, genuine portrayal of family and friendship. It illustrates the joys and struggles of life in the early pioneer days on the prairie,? says Vivienne M. St. John, Theater for Youth?s producing director.??I think especially during the whirlwind of the holidays, A Little House Christmas helps us to refocus and appreciate the simpler things and remember what is truly important."

Length:?One hour and 15 minutes with intermission?

Ticket price: $12- $16; recommended for pre-kindergarten and up

?

A Christmas Carol ? A Ghost Story of Christmas

When: Through Dec. 24, various times.

Where:? Alley Theatre, 615 Texas Ave., 713-220-5700, www.alleytheatre.org??

Storyline:? Three spirits visit Ebenezer Scrooge on Christmas Eve ? the ghosts of Christmas past, present and future. This production, Michael Wilson?s adaptation of the Charles Dickens classic, offers unusual twists and spectacular sets.

?What?s interesting to me about this tale is that we meet the indifferent and miserly Scrooge," says director James Black, "and he is shown by the Spirits that, ultimately, he has little power or affect on the people in his life and the world around him.

"He wants and needs the rest of humanity to be as miserable as he is. But the people endure and find joy and happiness and love in the simplest things and in the worst of times. Conversely, as we watch Scrooge?s transformation, he is shown that the tiniest act of kindness, compassion and charity can have ripples and reverberations that change lives. Love and generosity win. Every time."

Length: One?hour and 47 minutes with intermission

Ticket price:?Starts at $25; recommended for general audiences, children 6 and older

?

Sanders Family Christmas

When: Through Dec. 31, various times.

Where: A.D. Players, 2710 W. Alabama, 713-526-2721, www.adplayers.org??

Storyline:? The show spreads holiday cheer through more than 20 Christmas carols and yuletide stories. The Sanders family gathers for Christmas Eve 1941 in Mount Pleasant, N.C. It?s just before American soldiers, including a member of their own family, leave for World War II.

?The show is really all about family. Everyone can relate with at least one member of the Sanders family; the uncle who is a bit of a black sheep, the mother who embarrasses her children, the sister who has to be the center of attention,? says Sarah Cooksey, A.D. Players public relations manager.

?What makes the show even better is the great music and the chance for the families of Houston to enjoy a show together for the holidays. Sanders Family Christmas celebrates the things that mean the most in life: family, faith, and the joy that comes from experiencing them together with the people you love.?

Length: Two hours and 15 minutes including intermission

Ticket price: $32- $41

?

Houston Ballet?s The Nutcracker

When:?Through Dec. 30, Various times

Where: Wortham Theater Center, Brown Theater, 501 Texas Avenue, 713-227-2787, www.houstonballet.org

Storyline:?This is the beloved ballet with music composed by Peter Ilyich Tchaikovsky. It tells the story of little Clara who receives a magical nutcracker doll on Christmas Eve. After everyone goes to bed, she travels on a fantastic journey through the Land of Sweets, encountering the Mouse King and the Sugar Plum Fairy.

More than one million people have seen this Ben Stevenson production since its Houston Ballet premiere 25 years ago.?

?In keeping with traditions, The Nutcracker signifies the start of the holidays,? says principal dancer Mireille Hassenboehler, ?Seeing The Nutcracker is such a magical experience for families, from the growing Christmas tree to the snowy snow scene. What better way to elevate the holiday? The Nutcracker brings such beautiful set designs, amazing costumes, music by Tchaikovsky, and spectacular dancing.?

Length: One?hour and 55 minutes with intermission

Ticket price: $25-$110, recommended for children 2 and older.

?
?

Hip Hoppin? Nutcracker

When: Dec. 8; two shows 10 a.m. and 11:30 a.m.

Where: Jones Hall, presented by Houston Symphony, 713-224-7575, www.houstonsymphony.org

Storyline: Conductor Robert Franz and the Houston Symphony orchestra join forces with Westside High School?s Inertia Dance Company in this musical holiday celebration with a playful twist.?Inertia is an elite performing ensemble that combines different dance elements from ballet to modern jazz to break dancing.

The concert song list includes "Suites from The Nutcracker" and "The Snow Maiden" as well as "Caribbean Sleigh Ride," "Brazilian Sleigh Bells," even the theme from The Pink Panther. Children can chime in during the Christmas Pops Sing-Along. All the wonderful holiday music may just draw Santa away from the North Pole for a break - he?s scheduled to make an appearance on stage! ? ? ??

Families can arrive early before the 10 a.m. concert or stay late after the 11:30 a.m. concert to participate in activities including an instrument petting zoo and arts and crafts.

Length:?One hour

Ticket price: $18 for children, $26 for adults

Bernadette Versoza is founder of?ParentsPost.com,?a website that covers new and exciting things for families to do in the Houston area.

Source: http://houston.culturemap.com/newsdetail/12-01-12-the-five-family-holiday-shows-you-dont-want-to-miss-lively-theater-for-lively-children/

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Sunday, December 2, 2012

Obama: Don't hold middle-class tax cuts hostage

President Barack Obama greets the crowd after speaking at The Rodon Group manufacturing facility, Friday, Nov. 30, 2012, in Hatfield, Pa. Obama spoke at the toy company about how middle class Americans would see their taxes go up if Congress fails to act to extend the middle class tax cuts. (AP Photo/Matt Slocum)

President Barack Obama greets the crowd after speaking at The Rodon Group manufacturing facility, Friday, Nov. 30, 2012, in Hatfield, Pa. Obama spoke at the toy company about how middle class Americans would see their taxes go up if Congress fails to act to extend the middle class tax cuts. (AP Photo/Matt Slocum)

(AP) ? President Barack Obama says it's unacceptable for some congressional Republicans to "hold middle-class tax cuts hostage" because they don't want tax rates to rise on the wealthy.

In his weekly radio and Internet address Saturday, Obama says the average middle-class family of four could pay $2,200 more in taxes next year after the fiscal cliff. He says Republicans could give families "a sense of security going into the New Year" by extending tax cuts for the middle class.

In the Republican address, Utah Sen. Orrin Hatch accuses Obama of a "classic bait-and-switch on the American people" amounting to a tax increase twice the size of what he campaigned on.

Hatch says Democrats are pushing what he calls a disastrous strategy.

___

Online:

Obama address: www.whitehouse.gov

GOP address: www.youtube.com/gopweeklyaddress

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-12-01-Obama/id-1d10b5f9f10046eba9cecaa3995ba684

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How, in the animal world, a daughter avoids mating with her father: Paternal 'voice' recognition

How, in the animal world, a daughter avoids mating with her father: Paternal 'voice' recognition

Saturday, December 1, 2012

Paternal recognition ? being able to identify males from your father's line ? is important for the avoidance of inbreeding, and one way that mammals can do this is through recognizing the calls of paternal kin. This was thought to occur only in large-brained animals with complex social groups, but a new study published today in the open access journal BMC Ecology provides evidence in a tiny, solitary primate that challenges this theory.

The study, led by Sharon E Kessler, finds that the grey mouse lemur (Microcebus murinus) ? a small-brained, solitary foraging mammal endemic to Madagascar ? is able to recognize paternal relatives via vocalizations, thus providing evidence that this is not dependent upon having a large brain and a high social complexity, as previously suggested.

Because grey mouse lemurs are nocturnal solitary-foragers living in dense forests, vocal communication is important for regulating social interactions across distances where visibility is poor and communication via smell is limited. Though the mouse lemur shares sleeping sites with other mouse lemurs, it forages alone for fruit and insects. It is a particularly interesting species with which to study vocal paternal recognition because, in the wild, females remain in the same area of birth and cooperatively raise young with other female kin. Males do not co-nest with their mates or young and provide no paternal care, which limits opportunities for familiarity-based social interactions. Thus, vocalizations are likely to be important ? particularly for avoiding inbreeding.

The research team from Arizona State University and the University of Veterinary Medicine Hannover in Germany found that two of the most frequent calls of the mouse lemur were the mate advertisement call and the alarm call. Using multi-parametric analyses of the call's acoustic parameters, they could see that both call types contained individual signatures. Through this, they discovered that only male grey mouse lemur advertisement calls, but not alarm calls, contained acoustic paternal signatures. Furthermore, females paid more attention to advertisement calls from unrelated males than from their fathers.

The findings from the study suggest that the discrimination between mate advertisement calls and alarm calls may be an important mechanism for inbreeding avoidance. This is likely to be highly important in the grey mouse lemur species because males are likely to remain in an area for several years and they can expand their ranges to more than twice that of the female's range, making it likely that adult males' ranges will overlap with those of their daughters from previous mating seasons.

The team also proposed that the mouse lemur's ultrasonic calls above the hearing range of owls could be an anti-predator strategy, especially since the species suffers from high predation.

Lead author Kessler commented, "Given that more complex forms of sociality with cohesive foraging groups are thought to have evolved from an ancestral solitary forager much like the mouse lemur, this suggests that the mechanisms for kin recognition like those seen here may be the foundation from which more complex forms of kin-based sociality evolved."

She continued, "Future analyses will determine which acoustic parameters make this kin recognition possible by artificially manipulating acoustic parameters in the calls and then using the modified calls in playback experiments."

###

Paternal kin recognition in the high frequency / ultrasonic range in a solitary foraging mammal
Sharon E Kessler, Marina Scheumann, Leanne T Nash and Elke Zimmermann
BMC Ecology (in press)

BioMed Central: http://www.biomedcentral.com

Thanks to BioMed Central for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/125623/How__in_the_animal_world__a_daughter_avoids_mating_with_her_father__Paternal__voice__recognition

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ISLAND HOUSE TO ?ELIMINATE DOGS?? ? Pet City

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Island House will soon need a Dogs NOT Welcome sign.

Island House is a small condo complex on Hilton Head Island, SC. In a recent letter to homeowners from ASSOCIA, Association Services Management, Inc.,?signed by Marv DeGraw, ?President?? of what the letter doesn?t say?they are asking homeowners to agree to the ?ELIMINATION? (my emphasis) of all dogs except Seeing Eye dogs. Despite the violation of the ADA which allows ALL SERVICE DOGS ANYWHERE, not just seeing eye dogs,? as a dog lover, and animal rights defender, I?DETEST the use of the word ELIMINATION. Mr. DeGraw and this organization are not only out of touch with the reality of how dogs are an integral and essential part of family life and society, but could use a good thesaurus as their?word choice is draconian and demeaning to all pet parents at Island House and everywhere. GET WITH IT? pet travel?is increasing greatly, the recession didn?t?even make a slight decrease in the amount of money spent on pets as?shown in the statistics below. Don?t you realize a dog is a family member? These??certainly aren?t people I?d want in charge of my HOA.

After talking to some residents,? I found out that the majority of Island House Units are owned by off- property owners. These people rent out their condos?for long or short term periods. Taking kids to the beach more than ever includes the family pet and more luxurious locations on Hilton Head and elsewhere WELCOME PETS. How about the Hilton Head Westin Hotel? They have a fantastic Pet WELCOME policy even providing Heavenly Beds for? the dogs, food and water bowls, and treats. An owner?s investment in a rental property at Island House will diminish if they?re not able to offer their unit as Pet Friendly. What about people who rent out a unit at Island House as a transition to a home purchase when transferred there by their employment?? Do Island House owners want their property removed from every real estate list on the island for relocation? Is Rover to be left in a kennel for months while a suitable home for purchase is found?

But what about the owners that do live there? While the letter says the new regulation won?t affect current dogs in residence, will?the pet parent?be able to get another dog should their dog die? The letter doesn?t say they will and usually when a pet is ?grandfathered? in, a replacement is not allowed.?This is unconscionable, in particular to owners who are elderly. Dogs provide companionship, comfort, enhance the health of their owners by getting them out to exercise, and most of all make a house?whether it?s a small condominium or a mansion?a home. Where does Island House get the right to deny these property owners of ever having a canine companion in the future?

According to the 2011-2012 APPA National Pet Owners Survey, 72.9 million dogs are owned in the United States which equates to 46.2 U.S. households having a dog. Obviously in time, none of them will be a Island house. Dogs are not only family members, they are big business. According to Forbes Magazine, 92% of pet owners spent as much or more on their pets from 2010-2012. http://www.zoomroomonline.com/pet-services.html

Marv?s letter goes on to delineate what seems to be his personal dislike for dogs, and maybe life in general. He accuses owners of ?sneaking two dogs into a unit.? Does he make a habit of personally observing this? Where is the evidence that two dogs cause excessive damage? Quite the contrary as they keep each other company and ease anxiety of being alone. He takes offense that ?some dog owners even allow their dogs to pee on the white stones under the stairwells? and that ?poop on the grass is a constant problem.? Really? Ever think of putting up a container of bags for dog owners to use for cleaning up after their dog like every civilized city has visible everywhere and? Hilton Head Beach as well? How would you know a dog ?peed? on a stone unless you were on ready alert at all times watching them?

Marv goes on to say ?Dog abuses are hard to monitor.? Really? What do you mean here? Do you forget that this is where people LIVE?.this is their home. Does privacy end with?a purchase or lease at Island House? And again, you need someone to proof read your letter. I assume you don?t mean beating and maiming of dogs which is what ?dog abuse?? unfortunately means, but you must mean violations of your rules which appear completely without merit.

Marv goes on to say that ?most condo complexes no longer?allow dogs?? Do you have any statistics to prove this, because I have them to prove you WRONG. The trend in the United States today is toward?allowing more privileges for dogs like our neighbor to the North, Canada and most European Cities. There are restaurants that allow you to dine with your dog, airlines devoted to just pet travel, and most hotel chains allow dogs.

Service dogs perform many valuable services today and Island House will definitely face lawsuits if they only allow ?seeing eye dogs.? Dogs assist paralyzed individuals, there are hearing assistance dogs, dogs that are trained to retreive items from store shelves for people in wheelchairs,?or recognize the onset of a seizure. Dogs help kids become better readers, comfort people in nursing homes,?calm the distraught in hospitals at the bedside of a loved one in critical condition and?dozens of other services. Will police officers who have? a K-9 dog be barred from residence at Island House??Discrimination against these individuals is a serious problem for this company and Mr. DeGraw. Take a look at this website for more information: http://answers.yahoo.com/question/index?qid=20101124134608AAWVtPK

I urge the owners and tenants of?Island House to confront Mr. DeGraw on this issue and to attend their HOA meeting on January 19, 2012?conveniently scheduled for?9:00 a.m. when many people are at work and the?only people available will be Marv?who?obviously is available to monitor dog behavior at any time and others who also have plenty of leisure time.? Contact the Humane Society of the United States, PETA, the SPCA and other animal rights groups to help you.Find a way to make your vote count and vote for decency, kindness, tolerance, and the right of people to have their best friend by their side. Oh, you might want to think about electing a new President of whatever he is in charge of and a new?Board of Directors that actually live on the premises and have a sense of the value of dogs.

Tags: pets welcome

Source: http://blogs.dailymail.com/petcity/2012/11/30/island-house-to-eliminate-dogs/

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Why your next game console ought to be Watson | TechDiem.com

A few years ago, the gaming world was thrilled by the premise that the cloud (the Cloud!) could be harnessed to power games, too ? any game you wanted, anytime, on any device, served from data centers to you. Services like OnLive and Gaikai promised freedom from your hardware, the end of the lockout of exclusive games only available on one platform or another.

Reality disappointed: What we actually got was a limited library of not-new games (Homefront, anyone?), many of which you already owned, but even laggier than on your own hardware. Turns out traditional retail, game publisher, and hardware platform companies made it difficult for cloud gaming services to get the best games on the day of release, and even then the gameplay quality was slightly inferior.

But the concept of gaming in the cloud is still an idea worth pursing for a far greater promise: the ability to deliver an entirely new kind of game experience.

Historically, in games as in any other media, new distribution technologies enable new creative experiences. Pong wouldn?t have been possible without a new device plugged in to your TV. Internet-connected computers meant you could play Duke Nukem and Quake with other people online. The evolution of server technology brought massively-multiplayer games. The iPhone brought Angry Birds, a game designed for a touch interface, and so forth.

So why should a cloud gaming service be used to deliver the same old games as before that were built for a $250 machine?

What we should be wondering, then, is what new kinds of games and gaming experiences cloud delivery could inspire? Compared to the gaming hardware you own, a cloud gaming service could access much more computing power?with a limitless capacity to add processing. Consider after all that the most powerful supercomputer in the world, the Titan, is about 70,000 times more powerful than an Xbox 360. Granted the Titan costs a cool $100 million, which cuts out most households, but scaling back to basic and accessible data center prices would still offer many orders of magnitude more computing power than any current or near-future home console . (And this isn?t to say great gaming experiences are limited to powerful hardware?to the contrary mobile phones play compelling games, too. They?re just of a different sort.)

As for content itself, games purpose-built for the cloud do not yet exist ? ones that aren?t encumbered by the limits of processing power,?that would use the full advantage of many more, and more powerful, CPUs and GPUs. These ?supercomputer games? would open up creative possibilities far beyond what games of today are capable.

Imagine supercomputer games with vividly lifelike worlds and characters (and not the almost-real, uncanny valley of current-generation graphics), or a single battlefield with 50,000 other players playing at the same time ? or opponent AI on the level of IBM?s Jeopardy!-winning Watson. Supercomputer games could be dramatically different from anything you can play tonight at home.?I?m no game designer, but what if we could use real-time traffic data to fill the streets of the next Grand Theft Auto, or step into a computer-generated world that looks as compelling as the Lord of the Rings movies?

Now, there are many reasons, beyond the technological, that these games don?t yet exist: It would be prohibitively expensive to pay artists to create all those detailed graphics, and simple AI is good enough to defeat most any player at most any game. But the record of creative innovators is that eventually they find a way to stretch the available technology to its limit. And some gamemakers are already beginning to probe at the games you can create if you host some of the game in the cloud.

There is a nagging constraint to the cloud, of course ? bandwidth, which simply isn?t growing at the pace of Moore?s law. Network latency makes fast-twitch games, in which defeat is determined in microseconds (like with the top console genre, first-person shooters) hard to play over today?s internet. So, at least until the next engineering breakthrough, these supercomputer games might be designed around genres requiring slower player reflexes than, say,?Call of Duty or StarCraft.

Best of all, the only hardware you would need at home is a basic input device like a controller and a box to render the graphics, and it could be cross-platform so that you could play from a PC or Mac or any smartphone. As one for-instance, OUYA, the new open, Android-based console I back, could be great for a cloud-delivered game (hear me, developers?), and its notable that Sony bought up Gaikai and certainly has plans. ?(Full disclosure: ?OUYA also has an announced partnership with the relaunched?OnLive.)

Supercomputer games could be extraordinary. Now some intrepid game developers just have to make one.

Roy Bahat is Chairman of the open, Android-based game console company OUYA, and is former president of IGN. He is also on the faculty at UC Berkeley. Follow him on Twitter @roybahat

Article source: GigOM http://feedproxy.google.com/~r/OmMalik/~3/VyA-Mafbvls/story01.htm

Tags: Tech

Source: http://techdiem.com/2012/12/01/why-your-next-game-console-ought-to-be-watson/

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Reeling Texas cancer agency OK'd faulty $11M award

AUSTIN, Texas (AP) ? Leaders of Texas' embattled $3 billion cancer-fighting effort approved an $11 million grant to a biomedical company even though the proposal wasn't reviewed, according to an internal audit that deepens the troubles of a state agency that has been denounced in recent months by some of the world's top scientists.

The discovery was uncovered during an internal review of the Cancer Prevention and Research Institute of Texas, and its grant to Peloton Therapeutics Inc. in 2010 was among the first it handed out. The Dallas-based company's commercialization award remains one of agency's largest taxpayer-funded grants to date.

The Associated Press on Thursday first reported the audit's findings, which were later announced by the agency.

Tim Kutzkey, Peloton's acting chief executive officer, declined comment and referred questions to CPRIT. In a statement, the agency said the company was unaware that "CPRIT processes had not been followed."

The cancer institute is home to the nation's second largest pot of cancer-research money, behind only the National Institutes of Health, and has awarded nearly $700 million. But it has come under intensifying scrutiny as several scientists, including two Nobel laureates, resigned in protest claiming the agency was charting a new politically driven path that put commercial interests before science.

CPRIT said the internal review did not uncover problems with any other commercialization awards.

The Peloton revelation is the latest blow to CPRIT, which launched in 2009 to widespread acclaim among scientists and cancer survivors but has spent the past year unraveling. Dozens of scientists have resigned from the agency's peer review panels en masse in recent weeks, some of whom criticized the fund for "hucksterism" and "suspicion of favoritism" on their way out the door.

Pelton's application would have been presented to the agency's oversight committee by Jerry Cobbs, the agency's chief commercialization officer. Cobbs announced his resignation this month, and his last day was set for Friday.

Members of the oversight committee are appointed by Gov. Rick Perry and other state elected leaders. The panel has the final say on whether an award is funded, but under agency rules, all applications must be reviewed by an outside panel of peer reviewers who evaluate the scientific and commercial merits of the proposal.

The agency's statement did not explain how Pelton's application made it through the process without anyone noticing that a review never took place. It only said that Cobbs "improperly included" the proposal in a slate of other recommendations to the oversight committee in 2010.

Attempts by the AP to reach Cobbs were not immediately successful Thursday evening.

Bill Gimson, the executive director of CPRIT who vowed that his reeling agency would recover from the growing onslaught of criticism at its annual conference in October, said in response to the audit's findings that the agency must have the state's trust.

"We proactively initiated this comprehensive review in the effort to be transparent and ensure good stewardship," Gimson said.

Peloton's funding has been halted and the company's application is undergoing a second review, the agency said.

According to Peloton's most recent annual report to the CPRIT, which was obtained by AP, the company has attracted $18 million in outside investments since it was founded in 2010 by Steven McKnight, chairman of the biochemistry department at the University of Texas Southwestern Medical Center.

"Peloton Therapeutics aims to become a leading oncology company through the discovery and development of superior therapeutics, delivering extraordinary value to its employees, investors, and ultimately, cancer patients," according to the company's application summary.

CPRIT ? started behind a push led by cancer survivor Lance Armstrong and Perry ? spent most of its first five years basking in praise and industry awe of the unprecedented amount of taxpayer dollars committed to a state-run, cancer-fighting effort. But those plaudits abruptly gave way to rebukes starting in May, and the fissures came from within.

Dr. Alfred Gilman, the agency's chief scientific officer and a Nobel laureate, announced his resignation following a $20 million award that never received a full scientific review. The money was for a so-called incubator project at M.D. Anderson Cancer Center in Houston, one of the country's top research institutes.

Gilman accused the agency's oversight board of ramrodding the project through the application process, despite the proposal being just six pages long. Gimson has said the type of proposal didn't require a full scientific review under agency rules but has since conceded missteps in how that award was handled.

In wake of the Peloton findings, CPRIT announced it would institute new rules that require independent third parties to make sure grant review policies are followed. The agency said it will install a compliance certification process that will accompany every recommended proposal given to the oversight committee.

___

Follow Paul J. Weber on Twitter: www.twitter.com/pauljweber

Source: http://news.yahoo.com/reeling-texas-cancer-agency-okd-faulty-11m-award-020825760.html

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Friday, November 30, 2012

More Legal Woes for LiLo! Will She Go Back to Jail?

When Lindsay Lohan gets in trouble, she doesn't do it halfway. Early this morning she was arrested for allegedly assaulting a woman in a New York City nightclub -- and now Lohan has been charged with three more crimes in California, including lying to police.

Source: http://www.ivillage.com/lindsay-lohan-faces-new-criminal-charges/1-a-505494?dst=iv%3AiVillage%3Alindsay-lohan-faces-new-criminal-charges-505494

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What Will Happen When The Surface Pro Isn?t The Only Flagship Win8 Tablet In Town?

2012-11-30 13.58.43The Surface Pro launches in January, just after the holiday rush. It's a pricey bauble at $899 plus an extra hundred for the Touch Cover. But everyone is excited. This is the model most of the Surface sympathizers are waiting for. It has the full Windows 8 experience, a capable Intel chipset, and an ecosystem two decades in the making. But here's the problem: come January the Surface Pro could have serious competition from Asus, Samsung, Lenovo and maybe even HP. In short, what happens when the big guys finally catch up to Microsoft?

Source: http://feedproxy.google.com/~r/Techcrunch/~3/ItG7jS0KnNo/

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Part I: Charitable Contributions and Taxes for 2013: Explaining the ...

By Joseph Gillmer, Vice President, CCS

With the election in the rearview mirror, Congress and the White House are focusing on budgets and taxes. Specifically, they are attempting to avoid the so called ?Fiscal Cliff,? a scenario where a variety of Federal taxes will increase while across-the-board spending cuts will occur at the same time?January 1, 2013. There are several aspects of charitable giving that could be impacted by Congressional decisions (or lack thereof) for 2012, 2013 and beyond. Below is a breakdown of the key charity-related tax issues on the table that would be addressed by The ?Family and Business Tax Cut Certainty Act of 2012? (FBTCC Act of 2012,) a bill that has passed the Senate Committee on Finance but requires full passage in Congress to take effect. The bill would extend certain expired or expiring tax provisions through December 31, 2013. The staff of the Joint Committee on Taxation (JCT) estimates that enacting the bill would reduce revenues by about $205 billion from 2013 to 2022 period. More than 60% of that revenue reduction would arise from a two-year extension of relief from the individual alternative minimum tax (AMT.) The charitable tax deduction ?extenders? are a smaller, but important part of the FBTCC Act of 2012.

Individual Charitable Deduction Extenders

Charitable IRA Rollover

The Charitable IRA Rollover was first enacted with the passage of the Pension Protection Act in 2006. It provided the ability for individuals 70 ? or older to direct traditional or ROTH IRA funds to charitable organizations up to $100,000. These gifts to charitable organizations, while not tax deductible (because they were pre-tax assets,) allowed individuals to fulfill part or all of his or her Required Minimum Distribution. The Charitable IRA Rollover provision has required approval from Congress as part of tax ?extender bills? every year or two years since 2009. The latest provision expired at the end of 2011.

The FBTCC Act of 2012 would reinstate the Charitable IRA Rollover to the beginning of 2012 and extend it through 2014. The Joint Committee on Taxation and Congressional Budget Office estimate that the Charitable IRA Rollover would cost the federal government about $877 million in lost tax revenue for 2013 and 2014. That equates to $2.5 to $3 billion in charitable giving through the Charitable IRA Rollover in 2013 and 2014. While the permanent expiration of the Charitable IRA Rollover does not necessarily mean that charitable giving would drop by several billion dollars over the next two years (as many donors use the gift vehicle as a substitute for other types of giving as opposed to wholly new giving,) the loss in giving would number in the hundreds of millions of dollars ? real dollars that could be going to worthy causes.

Contributions of Capital Gain Real Property Made for Conservation Purposes

The FBTCC Act of 2012 that would extend the Charitable IRA Rollover would also extend for two years the increased contribution limits and carry-forward period for contributions of appreciated real property (including partial interests in real property) for conservation purposes. The Joint Committee on Taxation and Congressional Budget Office estimate that the extension of the enhanced contribution limits of capital gain real property for conservation purposes would cost the Federal Government about $132 million in lost tax revenue for 2013 and 2014.

Annual Gift Tax Exclusion

The annual gift tax exclusion is one change taking effect in January 2013. The annual gift tax exclusion amount, which is adjusted annually, will be $14,000 for 2013, as announced by IRS last week (Internal Revenue Bulletin 2012-45.) Taxpayers will be able to make gifts of up to $14,000 per person in 2013 without any federal gift tax consequences. This means that an individual can provide up to $14,000 to any number of individuals without owing federal gift taxes (as long as the gift does not exceed $14,000 to any ONE individual) While the annual gift tax exclusion is not in the category of charitable deductions (and separate from FBTCC Act of 2012,) many individuals take into account what he or she can give to family members in a given year when considering a budget for charitable support.

Business Charitable Tax Deduction Extenders

The FBTCC Act of 2012 also provides provisions to extend several charitable avenues for businesses.

New Markets Tax Credit

Through the New Markets Tax Credit (NMTC) program, the federal government has been able to leverage federal tax credits to encourage significant private investment in businesses in low-income communities. The program provides a 39%tax credit spread over seven years. Many nonprofit organizations have been able to utilize new markets tax credits as part of a larger campaign for their capital needs over the last several years.

The FBTCC Act of 2012 would provide support for two more years of the new markets tax credit, permitting a maximum annual amount of qualified equity investments of $3.5 billion each year. The Joint Committee on Taxation and Congressional Budget Office estimate a two-year extension of this proposal will cost the federal government $32 million in 2013 and 2014 and about $1.8 billion over a 10-year period ending in 2022.

Enhanced Charitable Deduction for Contributions of Food Inventory

The FBTCC Act of 2012 would provide a two-year provision that would allow businesses to claim an enhanced deduction for the contribution of food inventory. The Joint Committee on Taxation and Congressional Budget Office estimate a two-year extension of this proposal would cost the Federal Government $314 million.

Basis Adjustment to Stock of S Corporations Making Charitable Contributions of Property

The FBTCC Act of 2012 would provide a two-year provision that would allow S corporation shareholders to take into account their pro rata share of charitable deductions even if such deductions would exceed such shareholder?s adjusted basis in the S corporation. The Joint Committee on Taxation and Congressional Budget Office estimate a two-year extension of this proposal would cost the federal government $224 million.

Latest on the Federal Estate Tax

Under current law the federal estate tax exemption is scheduled to change from $5 million in 2012 to $1 million in 2013. In addition, the estate tax rate is scheduled to revert from the current 35% rate for assets in an estate transferring to non-charitable beneficiaries that exceed the $5 million exemption to 55% for assets that exceed $1 million.

What would that mean in terms of an impact on charitable giving? The Congressional Budget Office concluded in reports published a couple years ago that repealing the estate tax would reduce charitable bequests as much as 28%. It is thought that the lower the exemption, the more individuals would need consider whether to give a significant amount of assets to either charity or the Federal Government. At a higher exemption or no federal estate tax at all, more individuals would just transfer assets to heirs, which would be why charitable support would drop in a high exemption or estate tax repeal scenario.

The Future of the Federal Estate Tax

President Obama has voiced support for a federal estate tax for 2013 to follow the rates of 2009: $3.5 million estate tax exemption and a 45% estate tax rate. On the left, there are legislators who are in favor of allowing the exemption to revert back to $1 million and 55% tax rate. On the right, there are legislators who are in favor of a permanent repeal of the estate tax.

If Congress acts before the end of the year, it will likely be a compromise that will set the estate tax exemption between $3.5 million and $5 million with an estate tax rate of 35-to 45%. As mentioned above, if Congress does nothing, the exemption automatically drops to $1 million with a 55% rate, effective January 1, 2013.

* CCS does not provide legal or tax advice. Donors and potential donors need to consult with tax professionals.

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Source: http://ccsfundraising.wordpress.com/2012/11/30/part-i-charitable-contributions-and-taxes-for-2013-explaining-the-fiscal-cliff-and-outlook/

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How much will you pay for a green future?

TIMES are tough. When the UK government announced its new energy plans last week, newspaper headlines raged about how much household bills would rise to pay for cleaner power generation. They gave voice to a growing segment of the British public - wearied by the country's prolonged economic doldrums - that seems disinclined to pay for a greener future.

Ordinary Brits might understandably feel hard done by. Power companies have prospered mightily in recent decades, but the costs of green power will be visited on their customers, not their profits. Other Europeans, too, face a steep bill for climate change relief, but dire financial straits are hampering their efforts (see "Europe in 2050: a survivor's guide to climate change").

But while money is tight, so is time. The climate talks which kicked off in Doha, Qatar, this week, are unlikely to yield much progress towards a global deal to cut emissions. That will increase the need for meaningful national climate change strategies. While we shouldn't let governments and energy companies off the hook, they need public support and pressure to act. It's time we all thought hard about the price we're willing to pay for the future.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Thursday, November 29, 2012

Google's Horowitz: Facebook Is A Social Network Of The Past

google-plus-facebook-logosGoogle?s Bradley Horowitz did a pretty good Rocky Balboa impression on Wednesday, calling Facebook ? the reigning social champ ? a ?social network of the past? and accusing the network of getting advertising all wrong.

Horowitz, Google VP of social products, made his comments during a 15-minute conversation at the Business Insider IGNITION conference. (See the full video below.)

His biggest verbal jabs at Facebook were on the subject of advertising. Horowitz said Facebook is ?jamming? ads into users? streams and frustrating both users and brands in the process. He said Google may someday have ads on Google+, but it won?t be because Google needs to ?make next week?s payroll based on jamming ads at users in an inappropriate way.?

Horowitz compared ads on Facebook to a guy selling sandwiches in the middle of someone?s conversation.

?When you and I are having a conversation, the least opportune thing you could do is have a guy with a sandwich board run between us and try to sell me a sandwich. I?m trying to connect with someone. I?m trying to communicate in that sacred space of social connection. It doesn?t matter if I ?like? the sandwich. It doesn?t matter if it?s personalized with my favorite mustard. That is the wrong moment to try to dangle a sandwich in front of me.?

Horowitz joked about Google+ usage when only a small percentage of the audience raised their hands to say they?d used the service recently, but he also hinted that Google?s next published usage figures for Google+ will be impressive.

?We recognize that Google+ may not yet be the place where you go to wish your friends a Happy Birthday,? Horowitz told host Nicholas Carlson, before adding ??we aspire to that.?

Horowitz said that Google has a more ?holistic philosophy? about running a social product.

?Google+ is not attempting to chase the social networks of the past, we?re charting a new course,? he said.

When Carlson asked if the phrase ?social networks of the past? was a reference to Facebook, Horowitz said ?yes.?

In the film, Rocky Balboa was the underdog boxer that stunned the champion, Apollo Creed. One thing about that: Rocky wasn?t much of a talker, he just took care of business inside the ring. Google might do well to follow that path, as well.

Here?s the full interview via Business Insider.

Related Topics: Facebook | Google | Google: Google+ | Top News



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Source: http://marketingland.com/googles-horowitz-facebook-is-a-social-network-of-the-past-27449

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Blue whales use ballet to trick their prey

Like behemoth ballerinas, blue whales pirouette before lunging at their prey, a strategy that may help the giants ambush krill from below.

"This behavior probably improves the whales' chances to engulf the most krill possible," said study co-author Ari Friedlaender, a marine biologist at Duke University.

The new findings, detailed on Tuesday in the journal Current Biology, may shed light on how the enigmatic creatures hunt and devour their shrimplike prey.

Hungry giants
The blue whale, the world's largest living creature, can span up to 98 feet (30 meters) in length and weigh up to 200 tons (180 metric tons). This creature the size of a submarine uses its bristly, comblike teeth, or baleen, to filter tiny crustaceans called krill from the water. Antarctic whalers who opened up the massive bellies of blue whales often found up to 2,000 pounds (907 kilograms) of krill, though the sea giants probably don't eat that much every day, Friedlaender told LiveScience.

Because krill cluster in massive swarms, "they're perfect food for something like a baleen whale that wants to engulf a big amount of something at one time," Friedlaender told LiveScience.

While the marine mammals' diet is well-known, how they find their prey remains a mystery.

To understand these foraging behaviors, Friedlaender and his colleagues attached motion sensors to the backs of 22 blue whales using suction cups. They also attached a critter cam to one individual, which showed the ocean and part of the whale's head from the animal's point of view. [See Video as a Blue Whale Dives for Krill]

Underwater ballet
When Friedlaender's team analyzed the data, they found something completely unexpected.

The sensors, which captured several hours of data from each whale, revealed half of the whales doing full, 360-degree turns. Many of these underwater twirls occurred as whales dove for prey.

A blue whale typically spots a dense krill swarm by the dark patch it leaves on the water's surface as seen from below. Once the swarm is spotted, the whale surges upward toward the dark spot and opens its mouth to engulf the krill in one big gulp. But sometimes, it also whirls around as it performs this lunge.

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    4. Atom smasher creates new kind of matter

"As it opens its mouth it begins to roll over. It's a very energetically costly thing to do ? it's like a parachute opening and the whale slows down considerably," Friedlaender said.

The stealthy strategy may allow whales to anticipate the krills' escape route and adjust before the krill have a chance to cluster together out of reach, he added.

Because one dense krill patch could provide a day's worth of food, it makes sense to perfect their hunting strategies, even if it takes a lot of energy, the researchers write in the journal article.

Whales also turned just before and between dives, suggesting the rotations help the cetaceans scope out the location of prey.

"As in all cetaceans, the eyes are positioned laterally, and thus rolling the body should enhance panoramic vision in multiple dimensions," the researchers write.

Follow LiveScience on Twitter @livescience. We're also on Facebook and Google+.

? 2012 LiveScience.com. All rights reserved.

Source: http://www.msnbc.msn.com/id/49987245/ns/technology_and_science-science/

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Wednesday, November 28, 2012

iPad Mini Take Apart Video Released

November 2nd, 2012

We just released our iPad Mini Take apart guide. The guide shows you how to open the iPad Mini and remove the various components. The iPad Mini is fairly easy to open up, especially if you?ve opened other iPad models. The video is embedded below:


Source: http://www.powerbookmedic.com/wordpress/2012/11/02/ipad-mini-take-apart-video-released

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Gene linked to respiratory distress in babies

Gene linked to respiratory distress in babies [ Back to EurekAlert! ] Public release date: 27-Nov-2012
[ | E-mail | Share Share ]

Contact: Elizabethe Holland Durando
elizabethe.durando@wustl.edu
314-286-0119
Washington University School of Medicine

Some infants are more susceptible to potentially life-threatening breathing problems after birth, and rare, inherited DNA differences may explain why, according to research at Washington University School of Medicine in St. Louis.

The study is the first to identify a single gene ABCA3 that is associated with a significant number of cases of respiratory distress syndrome (RDS) in babies born at or near full term. RDS is the most common respiratory problem in newborns and the most common lung-related cause of death and disease among U.S. infants less than a year old.

Their findings will be published in the December 2012 issue of Pediatrics and are available online.

The research may lead to new diagnostic and therapeutic strategies for prevention and treatment to improve respiratory outcomes for babies.

"We found that mutations in ABCA3 account for about 10 percent of respiratory disease in babies born near their due dates," said Jennifer A. Wambach, MD, assistant professor of pediatrics and the study's lead author. "These are babies who we typically think should have mature lungs and breathe normally. While we have known for a while that RDS is a heritable disease, this is the first gene to account for a significant proportion of disease among infants that are full-term or nearly full-term."

RDS occurs when an infant's lungs don't produce enough surfactant, a liquid that coats the inside of the lungs and helps keep them open so the baby can breathe. If there isn't enough surfactant, an infant has to work hard to breathe and may suffer from a lack of oxygen. Premature infants are at especially high risk of RDS, as surfactant production increases as babies near term. However, 2 percent to 3 percent of term and near-term babies also develop RDS.

The researchers' findings suggest a range of possibilities, Wambach said. These include using the genetic knowledge to plan affected infants' births near hospitals with neonatal intensive-care units and developing medical therapies to target the abnormal protein resulting from these mutations.

Wambach said the researchers hope to identify additional genes that cause neonatal RDS and better identify babies at risk.

"But right now we're studying how these mutations function in the laboratory," Wambach said. "Statistical associations help guide us, but we also need to understand the biology of these mutations."

The research team including Aaron Hamvas, MD, and F. Sessions Cole, MD evaluated five genes known to be important for normal breathing immediately after birth. Hamvas is the James Keating Professor of Pediatrics and medical director of the newborn intensive care unit at St. Louis Children's Hospital. Cole is the Park J. White, MD, Professor of Pediatrics.

The team looked at five genes involved in the metabolism of lung surfactant by taking DNA samples from more than 500 infants of African and European descent, with and without respiratory distress, who were carried to term or near term. They evaluated the same genes in an additional 48 babies with especially severe respiratory distress to see if their findings applied to that group, and in a third group of 1,066 Missouri babies, to determine the frequency of the mutations in a general population.

In comparing babies with and without respiratory distress, they found that babies of European descent with respiratory distress were more likely to have a single mutation in ABCA3, one of the five genes tested, than the infants with no breathing problems. Babies of African descent with respiratory distress also were more likely to have single ABCA3 mutations, but this difference did not reach statistical significance.

More than one-quarter of the babies with especially severe respiratory distress had a single mutation in ABCA3. Infants who inherit two defective copies of the ABCA3 gene usually require lung transplantation for survival. However, this is the first study to show that a single mutation in ABCA3 predisposes infants to respiratory distress that can usually be treated with neonatal intensive care.

The researchers also found that 1.5 percent to 3.6 percent of babies born in Missouri carry a single ABCA3 mutation, leading the researchers to estimate that about 10 percent of RDS cases among term and near-term infants may be attributable to mutations in ABCA3.

"We picked five candidate genes and thought we would find rare mutations in all of the genes," Wambach said. "However, we found very few mutations in the other genes, and they were not associated with RDS. Our findings were really isolated to this one gene, ABCA3."

###

Wambach JA, Wegner DJ, DePass K, Heins H, Druley TE, Mitra, RD, An P, Zhang Q, Nogee LM, Cole FS, Hamvas A. Single ABCA3 Mutations and Risk for Neonatal Respiratory Distress Syndrome. Pediatrics vol. 130 (6), December 2012

Funding for this research was received from the National Institutes of Health (NIH). Support also comes from the Eudowood Foundation, the Children's Discovery Institute, the Saigh Foundation, and Kailos Genetics. NIH grant numbers are R01 HL065174, R01 HL082747, K12 HL089968, K08 HL105891, R01 HL054703, K08 CA140720-01A1.

Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Gene linked to respiratory distress in babies [ Back to EurekAlert! ] Public release date: 27-Nov-2012
[ | E-mail | Share Share ]

Contact: Elizabethe Holland Durando
elizabethe.durando@wustl.edu
314-286-0119
Washington University School of Medicine

Some infants are more susceptible to potentially life-threatening breathing problems after birth, and rare, inherited DNA differences may explain why, according to research at Washington University School of Medicine in St. Louis.

The study is the first to identify a single gene ABCA3 that is associated with a significant number of cases of respiratory distress syndrome (RDS) in babies born at or near full term. RDS is the most common respiratory problem in newborns and the most common lung-related cause of death and disease among U.S. infants less than a year old.

Their findings will be published in the December 2012 issue of Pediatrics and are available online.

The research may lead to new diagnostic and therapeutic strategies for prevention and treatment to improve respiratory outcomes for babies.

"We found that mutations in ABCA3 account for about 10 percent of respiratory disease in babies born near their due dates," said Jennifer A. Wambach, MD, assistant professor of pediatrics and the study's lead author. "These are babies who we typically think should have mature lungs and breathe normally. While we have known for a while that RDS is a heritable disease, this is the first gene to account for a significant proportion of disease among infants that are full-term or nearly full-term."

RDS occurs when an infant's lungs don't produce enough surfactant, a liquid that coats the inside of the lungs and helps keep them open so the baby can breathe. If there isn't enough surfactant, an infant has to work hard to breathe and may suffer from a lack of oxygen. Premature infants are at especially high risk of RDS, as surfactant production increases as babies near term. However, 2 percent to 3 percent of term and near-term babies also develop RDS.

The researchers' findings suggest a range of possibilities, Wambach said. These include using the genetic knowledge to plan affected infants' births near hospitals with neonatal intensive-care units and developing medical therapies to target the abnormal protein resulting from these mutations.

Wambach said the researchers hope to identify additional genes that cause neonatal RDS and better identify babies at risk.

"But right now we're studying how these mutations function in the laboratory," Wambach said. "Statistical associations help guide us, but we also need to understand the biology of these mutations."

The research team including Aaron Hamvas, MD, and F. Sessions Cole, MD evaluated five genes known to be important for normal breathing immediately after birth. Hamvas is the James Keating Professor of Pediatrics and medical director of the newborn intensive care unit at St. Louis Children's Hospital. Cole is the Park J. White, MD, Professor of Pediatrics.

The team looked at five genes involved in the metabolism of lung surfactant by taking DNA samples from more than 500 infants of African and European descent, with and without respiratory distress, who were carried to term or near term. They evaluated the same genes in an additional 48 babies with especially severe respiratory distress to see if their findings applied to that group, and in a third group of 1,066 Missouri babies, to determine the frequency of the mutations in a general population.

In comparing babies with and without respiratory distress, they found that babies of European descent with respiratory distress were more likely to have a single mutation in ABCA3, one of the five genes tested, than the infants with no breathing problems. Babies of African descent with respiratory distress also were more likely to have single ABCA3 mutations, but this difference did not reach statistical significance.

More than one-quarter of the babies with especially severe respiratory distress had a single mutation in ABCA3. Infants who inherit two defective copies of the ABCA3 gene usually require lung transplantation for survival. However, this is the first study to show that a single mutation in ABCA3 predisposes infants to respiratory distress that can usually be treated with neonatal intensive care.

The researchers also found that 1.5 percent to 3.6 percent of babies born in Missouri carry a single ABCA3 mutation, leading the researchers to estimate that about 10 percent of RDS cases among term and near-term infants may be attributable to mutations in ABCA3.

"We picked five candidate genes and thought we would find rare mutations in all of the genes," Wambach said. "However, we found very few mutations in the other genes, and they were not associated with RDS. Our findings were really isolated to this one gene, ABCA3."

###

Wambach JA, Wegner DJ, DePass K, Heins H, Druley TE, Mitra, RD, An P, Zhang Q, Nogee LM, Cole FS, Hamvas A. Single ABCA3 Mutations and Risk for Neonatal Respiratory Distress Syndrome. Pediatrics vol. 130 (6), December 2012

Funding for this research was received from the National Institutes of Health (NIH). Support also comes from the Eudowood Foundation, the Children's Discovery Institute, the Saigh Foundation, and Kailos Genetics. NIH grant numbers are R01 HL065174, R01 HL082747, K12 HL089968, K08 HL105891, R01 HL054703, K08 CA140720-01A1.

Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/wuso-glt112712.php

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Why the Susan Rice Haters Are Really So Upset with Her Talk-Show Talking Points

We've been looking at this Susan Rice controversy all wrong. Many people have puzzled as to why Republican senators, particularly John McCain, are fixated on what Rice said about the attacks in Benghazi during several Sunday talk-show appearances September 16. Rice had no role in securing the consulate, and she's not being asked to answer for its vulnerability. Instead, the dispute is very much about how closely she hewed to her talking points as a spokesperson for the administration on TV. If it all seems like a frenzy over something that matters very little to average American people and very much to a couple of long-serving American senators, you have to remember: talking points on talks shows are very, very important to the careers of long-serving senators. And Sunday talk shows are especially important to John McCain.

RELATED: Why America Still Listens to McCain

They even have a scorecard for this type of thing. In 2011, McCain fought back to second place on the list of most popular guests with?19 Sunday-show hits, just behind Michele Bachmann, who had 20. By November 27 of this year, McCain had recaptured the title, with?20 Sunday-show appearances.?Who's in second place? Lindsey Graham, McCain's partner in Rice-chasing. (He was No. 3 in 2011 and 2010.)

RELATED: Susan Rice to Face Her Haters

In her interview today with The New York Times' Maureen Dowd, Maine Sen. Susan Collins, a less popular guest, nevertheless reveals the centrality of Sunday-show hits in a senator's worldview. "If I wanted to be secretary of state," Collins told Dowd, "I would not go on television and perform what was essentially a political role." It's more a senators' thing. Collins didn't say she'd block Rice if Obama nominates her to Secretary of State. But she's shocked Rice hasn't remedied the talking points controversy in the way a senator might:

Collins is curious why Rice is not angrier, if, as she insists, she was repeating what she was told. ?I?d be furious at the White House and F.B.I. and intelligence community for destroying my credibility,? the senator said.

How should Rice express that fury? On a Sunday show, perhaps?

Source: http://news.yahoo.com/why-susan-rice-haters-really-upset-her-talk-155542815.html

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Online sales jump 24 percent early on Cyber Monday: IBM

SAN FRANCISCO (Reuters) - Online sales jumped during the first hours of Cyber Monday suggesting strong growth from earlier in the holiday shopping season continues, according to data from International Business Machines Corp.

Online sales were up 24.1 percent as of 12:00pm EST on Cyber Monday, compared to the same period a year earlier, said IBM, which tracks transaction data from 500 U.S. retail websites. In 2011, the early Cyber Monday year-over-year growth was 15 percent, IBM noted.

Strong online sales growth on Thanksgiving Day and Black Friday sparked concern that shoppers may just be buying earlier, threatening revenue later in the season.

"So far that is not the case," said Jay Henderson, Strategy Director, IBM Smarter Commerce. "Extending the shopping season has really just fueled additional online spending rather than cannibalizing days later in the season."

(Reporting By Alistair Barr)

Source: http://news.yahoo.com/online-sales-jump-24-percent-early-cyber-monday-180232079--sector.html

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The Eco-Innovation Observatory (EIO) would like to invite you to share your views on the role of eco-innovation in the shift towards a resource-efficient, low-carbon Europe. We would like to consult representatives from academia, business, civil society and public administration by taking part in our questionnaire. Your insights will be used in the upcoming reports of the Observatory, including our final flagship annual publication. The survey has only three questions and is entirely anonymous.

Please follow this link to the questionnaire.

For more information on the Eco-Innovation Observatory, see www.eco-innovation.eu

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