Tuesday, April 30, 2013

Leftist priests: Francis can fix church 'in ruins'

BUENOS AIRES, Argentina (AP) ? A new pope from Latin America known for ministering to the poor in his country's slums is raising the hopes of advocates of liberation theology, whose leftist social activism had alarmed previous pontiffs.

Prominent liberation theologian Leonardo Boff said Pope Francis has what it takes to fix a church "in ruins" and shares his movement's commitment to building a church for the world's poor.

"With this pope, a Jesuit and a pope from the Third World, we can breathe happiness," Boff said Saturday at a Buenos Aires book fair. "Pope Francis has both the vigor and tenderness that we need to create a new spiritual world."

The 74-year-old Brazilian theologian was pressured to remain silent by previous popes who tried to draw a hard line between socially active priests and leftist politics. As Argentina's leading cardinal before he became pope, Francis reinforced this line, suggesting in 2010 that reading the Gospel with a Marxist interpretation only gets priests in trouble.

But Boff says the label of a closed-minded conservative simply doesn't fit Francis.

"Pope Francis comes with the perspective that many of us in Latin America share. In our churches we do not just discuss theological theories, like in European churches. Our churches work together to support universal causes, causes like human rights, from the perspective of the poor, the destiny of humanity that is suffering, services for people living on the margins."

The liberation theology movement, which seeks to free lives as well as souls, emerged in the 1960s and quickly spread, especially in Latin America. Priests and church laypeople became deeply involved in human rights and social struggles. Some were caught up in clashes between repressive governments and rebels, sometimes at the cost of their lives.

The movement's martyrs include El Salvador's Archbishop Oscar Romero, whose increasing criticism of his country's military-run government provoked his assassination as he was saying Mass in 1980. He was killed by thugs connected to the military hierarchy a day after he preached that "no soldier is obliged to obey an order that is contrary to the will of God." His killing presaged a civil war that killed nearly 90,000 over the next 12 years.

The case for beatification of Romero languished under popes John Paul II and Benedict XVI due to their opposition to liberation theology, but he was put back on track to becoming a saint days after Francis became pope.

Scores of other liberation theologians were killed in the 1970s and 1980s. Six Jesuit teachers were slaughtered at their university in El Salvador in 1989. Other priests and lay workers were tortured and vanished in the prisons of Chile and Argentina. Some were shot to death while demanding land rights for the poor in Brazil. A handful went further and picked up arms, or died accompanying rebel columns as chaplains, such as American Jesuit James Carney, who died in Honduras in 1983.

While even John Paul embraced the "preferential option for the poor" at the heart of the movement, most church leaders were unhappy to see intellectuals mixing doses of Marxism and class struggle into their analysis of the Gospel. It was a powerfully attractive mixture for idealistic Latin Americans who were raised in Catholic doctrine, educated by the region's army of Marxist-influenced teachers, and outraged by the hunger, inequality and bloody repression all around them.

In the late 1960s and early 1970s, hundreds of Argentine priests were affiliated with a movement that proclaimed Christian teaching "inescapably obliges us to join in the revolutionary process for urgent radical change of existing structures and to reject formally the capitalistic system we see around us ... We shall go forward in search of a Latin American brand of socialism that will hasten the coming of the new man."

John Paul and his chief theologian, Cardinal Joseph Ratzinger, drove some of the most ardent and experimental liberation theologians out of the priesthood, castigated some of those who remained, and ensured that the bishops and cardinals they promoted took a wary view of leftist social activism.

Yet much of the movement remained, practiced by thousands of grassroots "base communities" working out of local parishes across the hemisphere, nurtured by nuns, priests and a few bishops who put freedom from hunger, poverty and social injustice at the heart of the Church's spiritual mission.

Hundreds of advocates at a conference in Brazil last year declared themselves ready for a comeback.

"At times embers are hidden beneath the ashes," said the meeting's final declaration, which expressed hopes of stirring ablaze "a fire that lights other fires in the church and in society."

Boff and other advocates are thrilled that this new pope spent so much time ministering in the slums, and are inspired by his writings, which see no heresy in social action.

"The option for the poor comes from the first centuries of Christianity. It is the Gospel itself," said then-Cardinal Jorge Mario Bergoglio during a 2010 deposition in a human rights trial. He said that if he were to repeat "any of the sermons from the first fathers of the church, from the 2nd or 3rd century, about how the poor must be treated, they would say that mine would be Maoist or Trotskyite."

Msgr. Gregorio Rosa Chavez, the auxiliary bishop of San Salvador, said Romero and Francis have the same vision of the church. "When he says 'a church that is poor and for the poor,' that is what Monsignor Romero said so many times," he said.

Rosa Chavez said neither was among the most radical of churchmen.

"There are many theologies of liberation," he said. "The pope represents one of these currents, the most pastoral current, the current that combines action with teaching." He described Francis' version as "theologians on foot, who walk with the people and combine reflection with action," and contrasted them with "theologians of the desk, who are from university classrooms."

John Paul II himself embraced the term "liberation theology," but was also credited with inspiring resistance to the communist regime in his native Poland, and was allergic to socialist pieties.

For 30 years, the Vatican has been seeding Latin America, Africa and Asia with cardinals "who have tended to be, adverse, to put it kindly, to liberation theology," said Stacey Floyd-Thomas, a professor of ethics and society at Vanderbilt University Divinity School.

In Brazil, Sao Paulo Archbishop Odilo Scherer, widely considered a possible pope, told the Estado de S. Paulo newspaper last year that liberation theology "lost its reason of being because of its Marxist ideological underpinnings . which are incompatible with Christian theology."

"It had its merits by helping bring back into focus matters like social justice, international justice and the liberation of oppressed peoples. But these were always constant themes in the teachings of the Church," Scherer said.

In 1984, Ratzinger put Boff in Galileo's chair for a Vatican inquisition over his writings, eventually stripping him of his church functions and ordering him to spend a year in "obedient silence." Nearly a decade later, in 1993, the Vatican pressured him again, and he quit the Franciscan order.

Now Boff says Francis has brought a "new spring" to the global church.

"Josef Ratzinger. He was against the cause of the poor, liberation theology," Boff said. "But this is from last century. Now we are under a new pope."

___

Associated Press Writers Michael Warren in Buenos Aires, Jenny Barchfield in Rio de Janeiro, Marcos Aleman in San Salvador and John Rice in Mexico City contributed to this report.

Source: http://news.yahoo.com/leftist-priests-francis-fix-church-ruins-213627659.html

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Monday, April 29, 2013

Syrian rebels, troops clash at military air bases

BEIRUT (AP) ? Syrian rebels seeking to topple President Bashar Assad fought intense battles with his troops on Sunday at two military air bases in northern Syria, activists said.

The fighting raged inside the sprawling Abu Zuhour air base in northwestern Idlib province and the Kweiras military air base in northern Aleppo province.

The Britain-based Syrian Observatory for Human Rights said at least seven fighters were killed in the fighting in Abu Zuhour, in addition to an unknown number of soldiers. The group, which relies on a network of activists on the ground, said the Syrian air force conducted an airstrike on Abu Zuhour village during the fighting to ease pressure on government troops inside the air base.

Rebels control much of Idlib and Aleppo provinces, which border Turkey, although government troops still hold some areas including the provincial capital of Idlib province and parts of the city of Aleppo, Syria's largest urban center.

The fighters entered the two air bases on Saturday. Both have been under siege for months.

Syria's conflict started with largely peaceful anti-government protests in March 2011 but eventually turned into a civil war. More than 70,000 people have been killed, according to the United Nations.

The Obama administration said Thursday that intelligence indicates that government forces likely used chemical agents against rebels in two attacks.

Washington's declaration was its strongest on the topic so far, although the administration said it was still working to pin down definitive proof of the use of chemical weapons. It held back from saying Damascus had crossed what President Barack Obama has said would be a "red line" prompting tougher action in Syria.

Both sides of the civil war accuse each other of using the chemical weapons.

The deadliest such alleged attack was in the Khan al-Assal village in the Aleppo province in March. The Syrian government called for the United Nations to investigate alleged chemical weapons use by rebels in the attack that killed 31 people.

Syria, however, has not allowed a team of experts into the country because it wants the investigation limited to the single Khan al-Assal incident, while U.N. Secretary-General Ban Ki-moon has urged "immediate and unfettered access" for an expanded investigation.

The state-run al-Thawra newspaper on Sunday accused the U.N. secretary general of being a "tool" for the United States and accused him of "bowing to American and European pressures."

In neighoring Lebanon, Hezbollah's Al-Manar TV reported that Russia's Deputy Foreign Minister Mikhail Bogdanov met Saturday night with the pro-Syrian militant group's leader, Sheikh Hassan Nasrallah. No details emerged of the late night meeting.

The Shiite Muslim group has been drawn into the fighting in Syria and is known to be backing regime fighters in Shiite villages near the Lebanon border. The Syrian opposition accuses fighters from the group of taking part in the Syrian military crackdown inside the country.

At a Sunday morning at a news conference in Beirut, Bogdanov called for a diplomatic solution to Syria's civil war based on the Geneva Communique of June 2012. The communique is a broad but ambiguous proposal endorsed by Western powers and Russia to provide a basis for negotiations.

Source: http://news.yahoo.com/syrian-rebels-troops-clash-military-air-bases-093439798.html

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Apple iPhoto (for iPhone)


It will come as no surprise that one of the slickest iPhone photo apps comes from the tech design leader: Apple. The company's iPhoto app for Mac OS X broke new ground in cool photo app interface features like skimmable gallery thumbnails and organizing your pictures in "Events." You get iPhoto for iPhone and for iPad with a single $4.99 purchase at the iTunes App Store. Of course, you can do a lot more with a tablet's bigger screen size, not to mention the much larger size and input capabilities of a desktop computer, but Apple nevertheless manages to make a lot of what makes iPhoto great available on its smallest screen.

The iOS version of iPhoto even adds a cool sharing feature you don't get on the desktop iPhoto app, the Photo Journals online Web photo galleries. It also takes advantage of iCloud Photo Streams, an extremely convenient way to get your photos to appear on all your Apple devices?and even on your Windows PC with iCloud installed.

Since it's what Apple calls a "universal" app, iPhoto for iOS works on the iPhone 4 and later, the iPod touch 4th generation and later, and the iPad 2 and later.

Interface
Nobody does interfaces as beautifully as Apple. Occasionally, the beauty and slickness of the interface design can actually make it less clear, until you get the hang of it.

iPhoto's remarkable user interface features multitouch gestures for photo correction, brushes for applying effects onto specific areas of a photo. Some nifty organization tools include the ability to identify similar photos with a double-tap, as well as to flag, favorite, or remove images. As with any good photo editor, iPhoto offers a simple button that takes you right back to your original image view.?

Interface
The home screen in iPhoto for iPhone looks different from that of the iPad version. Instead of the tablet's tabs, it shows five buttons across the bottom: Albums, Photos, Events, Journals, and Settings. The first shows your standard iPhone photo albums, including Camera Roll and Photo Stream. Tapping Photos displays a thumbnail grid all the photos on your device, and tapping on any of these opens a full view of the photo, with a filmstrip of the rest in the album sliding along the bottom of the screen?or along the left if you hold the phone in landscape view.

An "i" button shows info for the photo at hand, including any comments on Facebook or Flickr if you've previously shared it there. A Settings option lets you turn on Help overlay tooltips that explain exactly what each button does. One button at top right lets you quickly view the original image after any amount of edits.

You then tap the Edit button to start working on an individual image. This doesn't change the interface drastically, but just adds different buttons along the bottom, for Auto-Enhance, Rotate, Flag, Favorite, and Tag. But in front of all those is a suitcase button?representing your "toolkit" of photo-editing tools. These include Crop & Straighten, Exposure, Color, Brushes, and Effects. I would have preferred to see more than one Auto option, however, with different options separated out for brightness, color, and so on.

Basic Photo Adjustments
Adjusting your photo's exposure is handled in a way that's innovative for the touch interface: A bar along the bottom represents the image from its darkest to lightest tones, and you can either use controls on this bar or swipe up or down anywhere on the image to increase or decrease brightness, and right or left to do the same for contrast. It's sort of a histogram without the graph. The Apple-award-winning Snapseed for iPad uses a similar swiping approach, but both have the drawback of not letting you zoom while in this adjustment mode.

The artist's palette icon offers the four adjusters shown along the bottom?saturation, blue skies, greenery, warmth. ?Just swipe up or down to increase or decrease saturation and left and right to change hue. The tool is intelligent enough to adjust greenery if you start swiping on the grass, or warmth if you swipe on a person's skin. If you place your finger on sky blue, the option changes to darken or brighten the intensity of the sky?a nice trick.

A settings gear icons offer a healthy selection of white balance options?sun, clouds, shade, flash, face balance?or you can choose a neutral point in the image for a custom white balance. The face balance option can find a face in your photo and balance the rest of the photo based on that.

Cropping and straightening is also cleverly implemented. You can pinch and zoom within a set crop frame, or resize the frame with or without preserving aspect ratio. But neatest of all is the ability to level by holding the iPhone at an angle after tapping on the compass-like control below the photo. This takes advantage of the device's accelerometer. You can also just twist two fingers on the photo (the way most people will probably do it).

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/GwNzFMQTseA/0,2817,2418225,00.asp

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How Jurassic Park's Fearsome Robo-Rex Got Its Skin

It's one thing to make a giant, robotic Tyrannosaurus Rex. It's another thing entirely to make it look remotely real. Granted, a robo-rex is awesome in its own right, but it's just not quite the flavor of monster fit for a film like Jurassic Park. And so it was practical effects to the rescue yet again with a carefully applied dino-skin. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/TOUw16deEiU/how-jurassic-parks-fearsome-robo+rex-got-its-skin

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Educational rights for women remain motionless in Turkey | The ...




ISTANBUL ? Despite major education initiatives and social reformations since the time of Ataturk, many girls in Turkey still do not receive an education.

Mustafa Kemal, now better known as Ataturk, or ?Father of Turks,? is credited with founding the modern Republic of Turkey and was the first president of Turkey. Ataturk?s many social, political and economic reforms were embedded in the six fundamental principles of what is now known as ?Kemalism.?

These six principles include Republicanism, Nationalism, Populism, Statism, Secularism and Revolution. The latter two were vital in the emerging role education has played in Turkey throughout the past decades.

?Kemalism was one of the main reasons that education and literacy increased and spread around girls and boys ?equally? after the establishment of the Republic,? said Nesrin Ersoy McMeekin, an instructor at Koc University, a private university in Istanbul.

A leisurely park in Istanbul overlooks the Blue Mosque, a historic site where Turkish sultans once lived.

A leisurely park in Istanbul overlooks the Blue Mosque, a historic site where Turkish sultans once lived. Photo submitted by Kate Riley.

?Still, it was and is a slow process, but since man and woman are considered equal by law, it became the government?s duty to provide equal education for both sexes,? McMeekin said.

?Principles of Kemalism were very strongly ? and unfortunately sometimes wrongly ? used in education in different periods of the Republican era. Right now there is a big battle of keeping some of them and/or destroying them.?

As a professor of higher education, as well as someone who grew up in the Turkish education system, McMeekin has experienced challenges due to lack of funding for public education in Turkey, much like the monetary problems faced in the United States. She also sees how familial relations play a major role in the education of both young girls and boys, whether positively or negatively.

Although primary school is mandatory just as it is in the United States, many children, particularly girls, are not enrolled due to ?traditional values? sought by parents, according to the United Nations Girls? Education Initiative (UNGEI). This problem occurs primarily in the eastern parts of the country, which are considerably more rural and conservative.

Tolga Tan is a second-year Koc student who grew up in Kadikoy, Istanbul and is passionate about his own education. Tan has seen the impact families seem to have in various parts of the country.

?In rural areas, getting some sort of education has traditionally been a challenge,? Tan said. ?Most people in the eastern part of Turkey usually complete only primary education. The gender role in rural parts is more pronounced than it is in urban parts. Many girls don?t receive any education although it is unconstitutional, and this is mainly due to the parents and what they call ?traditional.??

According to the UNGEI and the United States Embassy in Turkey, the main obstacles to school attendance for girls in Turkey include a lack of school facilities, gender discrimination, low expectations from education, low quality of education and the cost associated with families sending their children to school.

Many children, particularly girls, are not enrolled due to ?traditional values??

UNGEI exemplifies the problem by outlining Van, a small town in eastern Turkey that demonstrates how poverty and cultural traditions have historically kept girls at home. Many families are worried an education could ?spoil their daughters for marriage,? according to the report. But through the efforts of the UNGEI, more and more of these families have altered their opinions in order to change their family?s educational legacy.

?It is true that if the parents have higher education it is more likely that their kids will have one as well,? McMeekin said. ?But there is also a significant number of parents who would do everything to have their kids go to university just because they themselves didn?t have the chance.?

Both Tan and McMeekin believe the amount of money pumped into education from the government could be increased, which might financially encourage families to make more of an effort in regards to their children?s education.

According to the United States Embassy in Turkey and the UNGEI, part of the problem lies in the cost of transporting a child to school and buying supplies. This could be solved with the creation of scholarships to improve attendance rates in public primary, secondary and higher education in the eastern parts of Turkey.

Public universities in Turkey generally cost about 400 Turkish Lira per semester, which is equal to about $222.60 in the United States, or they are free of charge. But students must go to primary school and follow the system in order to eventually take the university entrance exam during their final year of high school. At this point, there are a number of scholarships given if needed, McMeekin said.

But the campaign ?Hey Girls, Let?s Go to School? has seen challenges that inhibit some children from eventually reaching these upper levels of education. Although the UNGEI has seen persistent poverty and a lack of resources in rural Turkish areas that continue to harm the potential of the nation?s education system, it has also seen increased media visibility and support from prominent politicians including the Prime Minister and the first lady of Turkey since its 2003 inception.

Additionally, the number of female children not enrolled in primary school has decreased significantly since 2003, according to World Bank analyses. In 2003, the number of girls not in primary school in Turkey was about 253,000, while that number shrank to about 53,000 in 2010.

?In the last 15 to 20 years, emphasis on education and campaigns to support girls and kids from rural areas in getting education have increased significantly,? McMeekin said. ?But is it enough? Not yet. There is still a huge prejudice against girls? education in Turkey, especially in eastern Turkey.?


Education, international, Istanbul, study abroad, Turkey, UNGEI, Women's Rights

About Kate Riley

Kate is a junior Journalism major with minors in Psychology and International Studies, with a concentration in the Middle East. She is also a former Special Projects Editor, Copy Editor and Copy Intern with The Pendulum and served as the Editor-in-Chief of The Edge. View all posts by Kate Riley ?

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Source: http://www.elonpendulum.com/2013/04/educational-rights-for-women-remain-motionless-in-turkey/

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Thursday, April 25, 2013

Microsoft to unveil 'new generation' Xbox on May 21

Turns out, that "special event" that Microsoft has been rumored to have in store next month is real. The Redmond, Wash.-based tech giant sent out invitations this morning asking reporters to "join us as we reveal a new generation of Xbox."

There you have it. Just a month before E3 and almost exactly three months after Sony unveiled the PlayStation 4, Microsoft is planning to unveil its contender for the next-generation of the video game console wars.

The unveiling sounds like it won't have quite the same pomp and circumstance as Sony's dramatic unveiling of the PS4 at New York City's Hammerstein ballroom, however. The event is scheduled for 10 a.m. PT on May 21, and will take place at Microsoft's Xbox Campus in Redmond.

Details are predictably scarce ? all the invitation says below the iconic Xbox logo and the tagline "a new generation revealed" is, "Don Mattrick [President of Microsoft's Interactive Entertainment Business] and the Xbox team invite you to the Xbox campus for a special unveiling." If dropping the "Xbox" name four times in a single e-card isn't enough of a hint, you can't get much more unambiguous than the #XboxReveal hashtag placed at the bottom of the invitation.

Microsoft is (also predictably) trying not to divulge any unnecessary information about the new console, but all these hints suggest that preliminary reports were correct in predicting the next-generation device will simply be called "Xbox," like its first-generation counterpart that was originally released in 2001.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2b1fb9d9/l/0L0Snbcnews0N0Ctechnology0Cingame0Cmicrosoft0Eunveil0Enew0Egeneration0Exbox0Emay0E210E6C9583298/story01.htm

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Kansas judge blocks use of 'In Cold Blood' files

TOPEKA, Kan. (AP) ? A judge ruled Tuesday that investigation materials pertaining to the 1959 "In Cold Blood" murders that a Kansas Bureau of Investigation agent kept at home may not be auctioned off or publicly revealed until he's had a chance to review them.

Shawnee County District Judge Larry Hendricks said the state could face "irreparable harm" if the materials found in Harold Nye's home became public. The materials include Nye's personal journals, copies of records and other materials about the investigation that inspired the Truman Capote classic. Crime scene photos in his possession were returned to the state last year by his son, according to lawyers.

Ronald Nye, of Oklahoma City, kept the materials after his father's 2003 death and gave them to Seattle memorabilia dealer Gary McAvoy to auction off. But the Kansas attorney general's office contends the materials belong to the state, and it is suing to get them back. The case is scheduled to go to trial in November.

Hendricks said his order will remain in place until the case is settled, but he left open the possibility that he could rescind it after reviewing the documents to determine how much private material they contain.

"Folks, I think I need to see them," he said from the bench. "I need to look at them."

McAvoy and Ronald Nye now say they don't plan to auction off the materials, and that instead they plan to write their own book about the killing of Herb and Bonnie Clutter and two of their children at their remote farmhouse in Holcomb. Hendricks' order bars them from even speaking about the files' contents publicly.

The hunt for the killers mesmerized the nation and drew journalists from across the U.S. to the small western Kansas town. The state executed two parolees, Richard Hickock and Perry Smith, for the killings in 1965. Four years later, Harold Nye began a two-year stint as the KBI's director.

Capote's book about the murders, Hickock and Smith's trial and their executions is celebrated because it reads like a novel. However, scholars have debated its accuracy since it was published.

___

Follow John Hanna on Twitter at http://twitter.com/apjdhanna

Source: http://news.yahoo.com/kansas-judge-blocks-cold-blood-files-175907974.html

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Spain Lottery eyes 4.5 billion euro bond, or bridge loans: source

By Paul Day

MADRID (Reuters) - Spain's state-owned Loterias, or Lottery, may raise up to 4.5 billion euros ($5.9 billion) through a bond or by seeking bridge loans before eventually going to capital markets, a source at the economy ministry told Reuters on Tuesday.

Loterias y Apuestas del Estado, as the company is formally known, will move forward with the bond issue after it finalises a 1.5 billion euros syndicated loan for which it has received offers of 4.3 billion euros, the source said.

The source did not say what the funds would be used for, but said the idea was to give Loterias a credit rating and debt structure that would be helpful should the state decide to sell shares in the company.

Last year Loterias had planned to raise 6 billion euros in debt with the funds going to help Spain's government bail out the country's cash-strapped autonomous regions. But the plan was scrapped in December when the regions needed less emergency liquidity than was originally thought.

The source said that the current plan for Loterias was to give it a debt load of two times EBITDA (earnings before interest, taxes, depreciation and amortization) as had been recommended by external advisors two years ago when there was a plan for Loterias to launch shares on the stock market.

"All the external advisors argued that for the appropriate pricing of a company and for it to obtain a (debt) rating and have it objectively priced by the market, there was a case for debt of twice EBITDA," the source said.

He said there was no short-term plan, however, to revive the Initial Public Offering, or IPO, plan for Loterias, but that the idea was to give the company a compatible debt structure and maximum flexibility if the time should come.

Spain's Treasury is advising Loterias on its debt raising.

Loterias boasts the world's biggest jackpot and is Spain's most profitable publicly owned company with net profit of 2 billion euros expected this year, up 10 percent from last year.

Loterias said last week that it had received 4.3 billion euros in offers for the syndicated loan from 19 financial entities, of which 10 were foreign.

In a statement, Loterias said that it would decide on overall volume and the loan price in the coming weeks.

On Tuesday the economy ministry source said the 4.5 billion euros bond issue would come as a second tranche after the syndicated loan is finalised.

(Writing by Fiona Ortiz; Editing by Julien Toyer; editing by Ron Askew)

Source: http://news.yahoo.com/spain-lottery-eyes-4-5-billion-euro-bond-170736653--finance.html

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Wednesday, April 24, 2013

PFT: Milliner revealed to have had five surgeries

PeadGetty Images

As this year?s crop of incoming players, especially those taken in the first two rounds, celebrate their new circumstances, they need to keep one thing in mind.

Several months from now, there?s a chance they will think those circumstances stink.

Rams running back Isaiah Pead fell right into that category last season, despite being the 50th overall pick in the 2012 draft.? Presumed to be the heir apparent to Steven Jackson, Pead became largely forgotten last year, sliding behind seventh-rounder Daryl Richardson.

?Honestly, I would call it miserable,? Pead said of his rookie season, via the University of Cincinnati official website. ?Miserable life.? Miserable four-five months.?

When the season finally ended, Pead packed up and left.

?I took off and I didn?t come back until it was time to,? Pead said.? ?I just wanted to stay out of this area, I came back for a couple days to pack up then all the memories and walking back into my house by myself, had a couple days by myself, I just needed to get out of that area.?

Pead is partially responsible for his misery.? He didn?t deal well with being demoted behind a guy taken 202 spots later, showing up late for a pair of meetings.

?I was literally fed up with football,? Pead said.? ?Not a quitter, not quitting, I was just tired of football.? Tired of practice for the day and I would just lay there play video games and whatnot because it was so miserable, so stressful.?

With a fresh opportunity coming from the departure of Jackson, Pead is ready to turn the page.

?Whole new era, whole new attitude, whole new team, whole new Pead,? Pead said. ??I?m not going to sit and linger on something, but I am one to not forget about a situation.? I am moving on from last year, last year is last year, but I have not forgot about last year.? I wouldn?t call it revenge, but the chip that I put on my shoulder is just a little bigger.?

He needs to perform more than a little better to erase the head start that Richardson earned in 2012.? While Pead finished with 10 carries for 54 yards, Richardson had 98 carries for 475 yards.

Pead also needs to hope the Rams don?t use one of their high draft picks on a rookie who?ll get a chance to in 2013 that which Pead couldn?t in 2012.

Source: http://profootballtalk.nbcsports.com/2013/04/23/dee-milliner-has-had-five-surgeries/related/

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When is Innovation Old News? | My Island View

The term ?innovation? has been thrown around through the halls of education for several years. Its creation in our education system is a stated goal by our Department of Education. It is a reason, although some would call it a justification, for charter schools being formed. Charter schools were supposed to lead the way to innovation for public education. A problem with innovation however is that we often do not know it when we see it.

The whole idea of innovation is that it is something new. The other part of that, which is implied, is that it is also a successful improvement. That may be the piece that prevents recognizing innovation in education. Teachers, when it comes to education, are a conservative group. Change comes slowly, and there is a comfort in holding on to what has worked in the past. This has long been reinforced by the many trends and fads in education that have come and gone. Teachers have been programmed to believe that whatever the change being mandated by the powers that be, it will be gone with the next change of power. ?If we wait a little while, this to will pass? becomes the educators? mindset.

The newness of innovation is probably its greatest obstacle to acceptance. Teachers generally rely on the tried and true methods, proven to work over a long period of time. Innovation requires a leap of faith on the part of educators that the innovation will be a success. Unfortunately for innovation, the conservative nature of educators does not support taking risks. It may have something to do with self-perceptions of many teachers that as ?content experts? they shouldn?t make public mistakes. Supporting innovation that fails would be a commitment to failure in the eyes of many educators. Obviously, this slows innovation acceptance.

This entire process has been further complicated by the rate of speed that technology moves and affects change. Committees, research and approval are very big parts of change in education. Today however, change comes faster and more significantly than in years past primarily because of the advancements in technology. These advancements continue to move forward regardless of anyone?s committee, research, or approval.

Collaboration has long been an element of learning. The term social learning is now creeping into discussions more and more giving collaboration a facelift. Face to face collaboration is the oldest and most easily recognized form. It is also a positive reason for department and faculty meetings. When learning individually we are good, but more often than not, learning collaboratively we are better. Technology tools for collaboration have moved collaboration to the forefront.

Now, let us combine collaboration with technology and see if it fits into our education system. Technology has most recently provided many tools, or applications for collaboration. Social Media is not one tool, but rather a network of many that overlap and intertwine. Educators can: join a Ning community,and meet a colleague from anywhere, converse on that site, connect and collaborate on Twitter, continue face to face collaboration on a Google Hangout, or Skype, collaboratively create and publish documents, presentations, Podcasts and videos. The potential ability for educators to harness this power and use it to model and guide learning for their students is mind-boggling to me, as a 40-year educator. It is only surpassed by the idea that the same potential ability in the hands of the students will take collaboration, creation, and learning even further.

We have labeled this innovation the Personal Learning Network. It is what we use to connect educators for collaboration beyond their buildings, districts, towns, and countries. It is technology-driven innovation that may profoundly affect education in regard to collaboration and professional development. It connects teachers with students, administrators, thought leaders, authors, and experts in all areas. It enables collaboration and creation on every level for educators to learn and teach. We become connected educators giving us insights and relevance that has been enabled by technology.

This innovation has been percolating for several years now, yet it has failed to be accepted as innovation. There is a growing gap between the adapters, or the connected educators, and the unconnected educators. The continuous discussions of the connected are directed and led by thought leaders and collaborative reflections, discussions, and content. The unconnected educators rely on the past and whatever direction is given by the powers that be in their districts.

If innovation is something new than the idea of technology-driven collaboration in the form of a PLN is old news and no longer innovation. Since it is no longer innovative, maybe educators will consider it, as a possible next step in education that will enable needed change. The idea that educators may be anti-innovative is my only explanation as to why the idea of a Personal Learning Network has not yet moved educators to accept it as a method to move educators, and education to a better place.

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Source: http://tomwhitby.wordpress.com/2013/04/23/when-is-innovation-old-news/

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?Bagram Batman? educates soldiers and civilians on safety in Afghanistan

Behold 'Bagram Batman!'

The intimidator, educator and safety enthusiast has a mission: to help keep soldiers and civilians deployed in Afghanistan out of harm's way.

To help Bagram Batman fulfill his destiny, the U.S. Army, along with AFN Afghanistan, has released a series of humorous public service announcements staring the camouflage-clad Dark Knight.

In the 30-second spots, Bagram Batman confronts soldiers on various safety violations around the base, like going running with headphones or smoking near flammable liquids.

After being roughed up, the soldiers say they'll be safer next time. To which Bagram Batman growls in his best Christian Bale voice, "Swear to me!"

Source: http://news.yahoo.com/blogs/sideshow/bagram-batman-educates-soldiers-civilians-safety-afghanistan-175612217.html

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Tuesday, April 23, 2013

Nigeria censors documentary in growing crackdown

LAGOS, Nigeria (AP) ? The documentary on a massive strike that paralyzed life in Nigeria features newspaper headlines, television news footage and other information widely known about a government gasoline subsidy that saw billions of dollars stolen by greedy companies and the nation's elite.

It also, according to Nigerian authorities, could spark violence and potentially threaten national security.

The 30-minute film called "Fuelling Poverty" has been online for months, but only recently Nigerian officials have refused its director permission to show it publicly in this oil-rich nation of more than 160 million people. While free speech is enshrined in this democratic nation's constitution, an ever-increasing drumbeat of complaints and critical articles about the administration of President Goodluck Jonathan has seen authorities increasingly target journalists and others.

The film, sponsored by Soros Foundation's Open Society Justice Initiative for West Africa, focuses on the protests around Jonathan's decision to remove subsidies on gasoline in January 2012. Life in Nigeria ground to a halt before unions backed down. Later, a report by lawmakers demanded businesses and government agencies to return some $6.7 billion over the subsidy program.

Ishaya Bako, who directed the film that features civil rights activists and Nobel Prize laureate Wole Soyinka, later applied for the right to show the film publicly. In a letter dated April 8, Nigeria's National Film and Video Censors Board told Bako that the documentary was "prohibited for exhibition in Nigeria."

"I am further to inform you that this decision is due to the fact that the contents of the film are highly provocative and likely to incite or encourage public disorder and undermine national security," the letter signed by board lawyer Effiong Inwang reads. "Please you are strongly advised not to distribute or exhibit the documentary film. All relevant national security agencies are on the alert."

Tanko Abdullahi, a spokesman for the board, initially told The Associated Press on Wednesday that the film wasn't banned, but was "denied classification." Later, in the same conversation, he acknowledged it couldn't be shown over unspecified "security issues."

"What is national security for Nigeria is different from that of the U.S.A.," Abdullahi said. "We made that determination because of the content of the film. That's why you have regulators."

The government's decision has seen more people watch the film online. It also has sparked outrage from human rights activists and press freedom groups.

"Instead of banning the documentary 'Fuelling Poverty,' authorities should look into the important questions it raises about corruption and impunity in the country's oil sector and at the highest levels of government," Mohamed Keita, an official with the Committee to Protect Journalists, said in a statement. "We urge Nigeria's National Film and Video Censors Board to overturn this censorship order."

The move to ban the film comes as Jonathan's government, which many voted for believing he would change the engrained interests and corruption of Nigeria's government, has grown increasingly unpopular as extremists carry out bombings and the state-run power company cannot offer stable electricity. During the strikes, government officials put increasing pressure on broadcasters not to show images of protests, which at one point saw tens of thousands in the streets of Lagos.

Today, journalists at a newspaper face forgery charges over a story that claimed the presidency would try to disrupt opposition parties. Security agencies have harassed reporters at a weekly newspaper that wrote about abuses by the military in its crackdown against Islamic extremists. And workers who ran a call-in radio show in the northern city of Kano face charges over talking about rumors surrounding polio vaccinations in the wake of at least nine women vaccinators being killed.

Despite the outcry, however, the apparent crackdown continues, only fueling more of the same apathy for Nigeria's government seen by those featured in the documentary.

"We don't have government. It's a whole big banana republic," barber Emmanuel Tom Ekin says in the film. "They've been coming telling us story all the time, deceiving us. And right now, in our faces, they are still deceiving us."

___

Online:

The "Fuelling Poverty" documentary: www.youtube.com/watch?v=LVq10BwzQoI

___

Jon Gambrell can be reached at www.twitter.com/jongambrellAP .

Source: http://news.yahoo.com/nigeria-censors-documentary-growing-crackdown-095715824.html

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Monday, April 22, 2013

Home floor lamp toronto Improvement Tips For Success | zdarma ...

Home floor lamp toronto Improvement Tips For Success

Home improvement is such a broad subject. Because it offers such a wide array of options, home improvement can seem a bit daunting and overwhelming. Most people may think they need a contractor to do these seemingly time consuming, impossible tasks. The thing is: you can do it yourself! This article focuses on teaching you how to complete simple, everyday home improvements by yourself, no contractor necessary. Before you know it, you will be so savvy in home repair, all of your friends will be knocking on your door for help with their homes!

Protect yourself when you change the blades in your utility knife. While changing the blade, wrap tape around the old blade before tossing it in the trash. By doing this, the sharp edges of the blade will be covered. When taking out the trash, or packing down the trash, the sharp edges will not be able to hurt anyone with the tape wrapped around them.

Use carpet samples to carpet a whole room! Retail stores often throw away their samples. Cut each sample up into smaller pieces and tack or glue them into place for free floor covering. Cut them in identically sized pieces for a tile effect or cut them in irregular geometric shapes for an abstract look.

Make some simple fixes around your home. Things like squeaky doors, sticky cabinets or worn out address numbers really make an impact on the potential buyer. It makes them wonder on how you actually take care of the home and may make them question whether or not they want to make an offer.

If you are looking to add some value to a property you are planning on selling, you should think about remodeling your kitchen. The kitchen is the family center. It is the single most critical factor in influencing buyers. If you recreate the kitchen in a home, the value of the home that you are trying to sell instantly increases.

A great way to increase the value of modern light fixtures Toronto a home is to clean out the grout in ceramic tile. This will instantly make old tile look newer, which, consequently, increases the value of your home. This is a quick fix that could mean a few extra dollars in the long run.

You should make sure that a home with any additions is properly zoned and has all of the licenses that the area requires. There are some people who will build additions without permission first. If an addition is not registered, your insurance company could refuse to give you full insurance.

Know your area. If your home is in a subdivision or small town, you do not want your home to stick out like a sore thumb. Look around before you decide to do any outer renovations, and try to fit in, at least a little. Homes that do not fit are homes that usually have a harder time should you ever choose to sell.

When doing home improvement projects on your house, sometimes remodeling unfinished areas offers the most affordable opportunities to increase the value and functionality of your home. Refinishing the basement of your home not only increases the amount of usable living space in your house, it also will give your home better market value.

Paint a room. If you are looking for a home improvement project that takes a bit of time and effort, then painting may be for you. Make sure you have all the proper equipment to do the project, and go for it. A freshly painted room can do wonders for any home.

Have a clear path and share it with everyone working on the home. Many issues that arise with home improvement, occur when people are not communicating their wishes with each other. Your partner may want a golden bathroom, but if you have not taken the time to discuss it, it could lead to problems down the road.

Be flexible with your time. While you may expect a project to be done in a few weeks, you may need to plan in advance for it to take a bit longer. Life can sometimes lighting stores in mississauga get in the way of project completion, so spare yourself from disappointment, by giving a little leeway.

Always shut off the water if working near pipes. Home improvement projects in the kitchen or bathroom may not always involve pipes, but shutting off the water can prevent any mishaps from becoming catastrophes. Know where your main water shut-off valve is, and use it any time you are working in these areas.

When you are trying to narrow down which home improvements to tackle first, a good plan is to make a wish list first, of everything that you would do if you could do it all. Go through your home and figure out what needs fixed and make a note of each item. Then you can begin to prioritize what items are the most pressing and what you can afford to fix first.

Before making renovations on your home, you should determine the amount of time you plan on living in your house. Your budget improvements will vary according to this estimate. If you plan on selling your home in the next year, you should make sure you renovate the parts of your house that interest potential home buyers.

When you are designing your kitchen, think hard about whether you want an open or closed kitchen floor plan. If you like to be able to talk with your family, watch television and generally know what?s going on in the rest of the house while cooking, you may want an open kitchen plan. However, if you would prefer for the kitchen clutter to stay hidden, you may prefer a kitchen with a door that can be closed.

See? That was not so gruelingly hard, was it? While home improvement may seem like it is something you should pay somebody else to do, you can save money and do it yourself! The do-it-yourself tips located in body of this article explain exactly how to do it, all the while making your tasks fun and easy. While following the tips provided in this article, your home is on its way to being the talk of the town, in a good way!


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Source: http://zdarma-hry.info/77/home-floor-lamp-toronto-improvement-tips-for-success/

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Is Anyone Actually Going to Buy an iBeetle?

The much-rumored iCar may have never made it into existence, but VolksWagen's Apple-themed car has finally been made official: the iBeetle offers up some pretty deeply ingrained Apple tech. But who's actually going to buy one? More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/y8CRQCnuMic/is-anyone-actually-going-to-buy-an-ibeetle

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Sunday, April 21, 2013

Revolutionary new device joins world of smart electronics: New flexible, transparent, photosensitive device

Apr. 19, 2013 ? Smart electronics are taking the world by storm. From techno-textiles to transparent electronic displays, the world of intelligent technology is growing fast and a revolutionary new device has just been added to its ranks. Researchers at the University of Exeter have developed a new photoelectric device that is both flexible and transparent. The device, described in a paper in the journal ACS Nano, converts light into electrical signals by exploiting the unique properties of the recently discovered materials graphene and graphExeter. GraphExeter is the best known room temperature transparent conductor and graphene is the thinnest conductive material.

At just a few atoms thick, the newly developed photoelectric device is ultra-lightweight. This, along with the flexibility of its constituent graphene materials, makes it perfect for incorporating into clothing. Such devices could be used to develop photovoltaic textiles enabling clothes to act as solar panels and charge mobile phones while they are being worn.

Photosensitive materials and devices such as the one developed at Exeter can, in the future, also be used for intelligent windows that are able to harvest electricity and display images while remaining transparent. Smart materials have almost unlimited potential applications from integral iPods and keyboards in clothing to electronic displays on glasses and goggles.

Saverio Russo, Professor of Physics at the University of Exeter said: "This new flexible and transparent photosensitive device uses graphene and graphExeter to convert light into electrical signals with efficiency comparable to that found in opaque devices based on graphene and metals.

"We are only just starting to explore the interfaces between different materials at very small scales and, as this research shows, we are revealing unique properties that we never knew existed. Who knows what surprises are just around the corner."

Metallic nanostructures in smart materials typically cause a haze that prevents them from being truly transparent. The photosensitive device developed at Exeter contains no metals and is therefore completely transparent but, as it can detect light from across the whole visible light spectrum, it is as efficient at sensing light as other recently developed opaque photoelectric devices.

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Story Source:

The above story is reprinted from materials provided by University of Exeter, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Freddie Withers, Thomas Hardisty Bointon, Monica Felicia Craciun, Saverio Russo. All-Graphene Photodetectors. ACS Nano, 2013; : 130418094258009 DOI: 10.1021/nn4005704

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/electronics/~3/eCtfkj2ncUw/130419121116.htm

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Saturday, April 20, 2013

China's Sichuan hit by earthquake, killing 2

BEIJING (AP) ? At least two people were killed Saturday when a powerful earthquake jolted China's Sichuan province near the same area where a devastating quake struck five years ago, with state media warning the casualty toll could climb sharply.

The government's seismological bureau said the quake hit shortly after 8 a.m. in Lushan county in the city of Ya'an, home to China's famous pandas.

The news office for the Sichuan provincial government said on its official microblog account that two people were reported killed in Lushan and that two townships had suffered severe damages.

A state-run China News Service, quoting unnamed local media, said more than 100 people may have been killed or hurt in the earthquake.

The seismological bureau initially measured the quake at magnitude-7, while the U.S. Geological Survey recorded it at 6.6-magnitude, powerful enough to cause severe damage. Its depth was shallow, less than 13 kilometers or 8 miles, which could magnify the impact.

The official Xinhua News Agency said that the quake rattled buildings in the provincial capital of Chengdu 115 kilometers, or 70 miles, to the east.

There are reports that the airport in Chengdu was closed shortly after the earthquake, and

State-run China Central Television reported the Chengdu airport was temporarily closed, and that delays and flight cancellations were expected.

Social media users who said they were in Lushan county posted photos of collapsed buildings and reported that water and electricity had been cut off.

A man who answered the phone at the Ya'an city government said telecommunications were cut and that medical and rescue teams are on the way to the area.

"I felt the strong quake this morning in my office. All drawers of the desk opened and some stuff on the table fell on the floor," said the man, who refused to give his name, as is usual with low-ranking Chinese government officials.

The epicenter lies along the same Longmenshan fault where the devastating 7.9-magnitude quake struck in May 2008, leaving more than 90,000 people dead or missing and presumed dead.

Source: http://news.yahoo.com/chinas-sichuan-hit-earthquake-killing-2-015533561.html

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Watch LG Use IPS Displays to Make Men Stop Peeing at a Urinal

After pranking elevator passengers to think they were falling with its IPS displays, LG has moved on to trick even more vulnerable suckers: males trying to pee at a urinal. This time, LG put its IPS displays right in front of a urinal and let two attractive women tease the restroom goers. It's pretty hilarious. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/e40dADbnzyY/watch-lg-use-ips-displays-to-make-men-stop-peeing-in-a-urinal

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Friday, April 19, 2013

Russian foreign minister tells West "don't isolate Assad"

By Daren Butler

ISTANBUL (Reuters) - In an implicit warning to international supporters of Syrian opposition forces, Russia's foreign minister said on Wednesday that efforts to isolate one side in the conflict would wreck the chances of a negotiated solution and help militant Islamists.

Sergei Lavrov said the Friends of Syria group, which is meeting in Istanbul this weekend, had so far had a negative influence on implementing a 2012 accord among world powers aimed at resolving the war through talks among all sides.

Friends of Syria links the United States, European powers, Turkey and Gulf Arab states who support the opposition and have demanded that President Bashar al-Assad surrender power.

The 2012 Geneva accord left open the question of Assad's exact fate. Russia says his exit from power must not be a precondition for a dialogue among Syrians to end the conflict which has killed more than 70,000 people.

Lavrov said pressing for the government's removal would increase the threats posed by militant Islamist groups such as the rebel al-Nusra Front, which formally pledged allegiance last week to al Qaeda leader Ayman al-Zawahri.

"One must understand that the more one bets on the isolation of the regime of Bashar al-Assad and a military solution, the more these threats will be felt," Lavrov said at a news conference with Turkish Foreign Minister Ahmet Davutoglu.

"If a mechanism is created that isolates one side in the conflict or is aimed at isolating one side in the conflict, then we simply lose the opportunity for dialogue and a search for paths to a resolution," Lavrov said.

He said he hoped the weekend meeting would be "pragmatic" and help to set up a dialogue between the different parties.

"Some key participants ... have assured me that they will seek a way to try to get a dialogue started. I very much hope that this is done and, second, that it is successful," he said.

WORST MONTH

Since the declaration by world powers in Geneva in June 2012, the war in Syria has grown worse. March saw the most casualties of any month in the conflict so far.

British Foreign Minister William Hague said at a G8 foreign ministers' meeting in London last week that the world had failed Syria and the situation was reaching catastrophic proportions.

Western powers want to see the end of the Assad family's 43-year rule but are loathe to intervene militarily. However, their stand has been complicated by the growing prominence in rebel ranks of Islamist fighters such as the Nusra Front.

Moscow last week also expressed concern with al Qaeda's role, calling them "international terrorists" who wanted to turn Syria into their main springboard in the Middle East.

The conflict pits the Sunni Muslim majority against Assad's supporters, largely from his Alawite community, and has drawn in Sunni and Shi'ite militants from elsewhere in the Middle East. The Alawite sect is an offshoot of Shi'ite Islam.

U.N. Security Council member Russia has blocked efforts to impose sanctions on Assad's government, vetoing three U.N. resolutions condemning his crackdown on opposition groups.

It also opposes arming the rebels.

The Istanbul meeting will discuss how to pressure Assad into accepting a negotiated settlement, according to diplomats.

In February, Syrian Foreign Minister Walid al-Moualem said in Moscow the Assad government was ready for talks with the rebels. But fighting has intensified and rebels have made gains, including pressing on the capital Damascus.

Representatives of Turkey, Egypt, Jordan, the United Arab Emirates, Qatar, and Saudi Arabia, the United States, Britain, Germany, Italy and France, will meet in Istanbul.

(Additional reporting by Steve Gutterman in Moscow; Editing by Angus MacSwan)

Source: http://news.yahoo.com/russian-foreign-minister-tells-west-dont-isolate-assad-195111077.html

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Tuesday, April 16, 2013

Bacterial security agents go rogue

Monday, April 15, 2013

CRISPR, a system of genes that bacteria use to defend themselves against viruses, has been found to be involved in helping some bacteria evade the mammalian immune system.

The results are scheduled for publication Sunday, April 14 in Nature.

CRISPR is itself a sort of immune system for bacteria. Its function was discovered by dairy industry researchers seeking to prevent phages, the viruses that infect bacteria, from ruining the cultures used to make cheese and yogurt. Bacteria incorporate small bits of DNA from phages into their CRISPR region and use that information to fight off the phages by chewing up their DNA.

Now scientists at the Division of Infectious Diseases of the Emory University School of Medicine and the Emory Vaccine Center have shown that Francisella novicida, a close relative of the bacterium that causes tularemia, and another bacterium that causes meningitis, need parts of the CRISPR system to stay infectious. F. novicida, which grows inside mammalian cells, employs parts of CRISPR to shut off a bacterial gene that would otherwise trigger detection and destruction of the bacteria by its host.

Because disabling CRISPR creates a weakened bacterial strain that is easily recognized by the immune system, the finding could accelerate vaccine development. But it is also a broader reminder that in biology, defensive tools can be co-opted for purposes of stealth.

"CRISPR systems are bacterial defenses, but we've found that bacteria can use them offensively to hide from the host immune system and cause disease," says David Weiss, PhD, assistant professor of medicine (infectious diseases) at Emory University School of Medicine and Yerkes National Primate Research Center.

The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system has attracted recent attention among scientists for its potential uses in genetic engineering and biotechnology, but its roles in gene regulation and evading host immunity have remained relatively unexplored, Weiss says.

Weiss first isolated strains of F. novicida that had defects in their CRISPR systems while working as a postdoc with Denise Monack at Stanford. F. novicida infects rodents and only rarely infects humans. It is a model for studying the more dangerous F. tularensis, a potential biological weapon. Weiss was looking for F. novicida genes that are important for virulence: causing disease in a live animal.

Intriguingly, he found a DNA sequence that has recently been shown to encode a protein of the CRISPR system. What they were doing in F. novicida during infection was a puzzle.

"The mutations have a strong effect in the bacteria," Weiss says. "The wild type will kill mice, while the mutants are eradicated after a couple days. But why would the bacteria need to defend against foreign DNA to cause disease in a mouse? It didn't make sense."

The researchers discovered that the bacteria require one of the CRISPR genes to turn off production of a lipoprotein ? part of the bacterial cell membrane -- when the bacteria infect mammalian cells. For immune cells, lipoprotein is like blood in the water for a shark. A little whiff excites them. So for the bacteria to survive undetected, they have to silence lipoprotein production.

Working with Weiss, graduate student Tim Sampson ? who is first author of the Nature paper -dissected which parts of the CRISPR system were needed to turn off the lipoprotein. The CRISPR system consists of genes encoding several proteins and also incorporates small bits of DNA from phages as "repeats" into the bacterial DNA. RNA produced from the repeats guides an enzyme called Cas9 to slice up the phage DNA.

Sampson and Weiss found that part of the F. novicida CRISPR system makes an RNA that directs Cas9 against the lipoprotein gene. Weiss says the Cas9 regulatory system allows F. novicida to tune down the lipoprotein efficiently at the times when detection could be harmful, while still keeping it around for its function ? still unclear ? when the bacteria are outside the host.

"The finding that Cas9 is regulating a bacterial gene rather than slicing up a phage gene appears to be new, although there were already some hints that CRISPRs had broader functions in other bacteria," Sampson says.

To show that their results were not peculiar to F. novicida, the researchers collaborated with the laboratory of Yih-Ling Tzeng, PhD, assistant professor of medicine (infectious diseases) at Emory. They generated a strain of Neisseria meningitidis -- a cause of meningitis infections in humans -- with a deletion in Cas9. The mutated strain displayed defects in its ability to adhere to, invade and replicate in human cells. This suggests that similar functions for Cas9 and CRISPR may be found in other bacteria.

"Most of the bacteria that encode Cas9 are either pathogenic, or can commonly be found in the human body," Sampson says. "I think our findings will encourage other scientists to re-examine the functions of Cas9 and CRISPR in other bacteria, to look at interactions with the host."

For example, some Streptococcus bacteria and Listeria have similar CRISPR systems, but any potential function in causing disease in humans has not been revealed. Weiss and Sampson plan to investigate further how Cas9 functions to shut off the lipoprotein gene in F. novicida and how Cas9 becomes activated.

Sampson is a student in Emory's Microbiology and Molecular Genetics graduate program.

###

Emory Health Sciences: http://whsc.emory.edu/home/news/index.html

Thanks to Emory Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127743/Bacterial_security_agents_go_rogue

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